Case Report

Metachronous Splenic Metastasis from Colonic Carcinoma Five Years After Surgery: A Case Report and Literature Review

Authors: Pierpaolo Sileri MD, MS, PhD, Stefano D’Ugo MD, Domenico Benavoli MD, Vito M. Stolfi MD, Giampiero Palmieri MD, Alessandra Mele MD, Achille L. Gaspari MD

Abstract

Abstract:Metastatic lesions of the spleen are a rare finding and are generally associated with widespread disease. Moreover, solitary metastases of the spleen are exceptional. In this paper, we describe the case of a patient who developed an isolated splenic metastasis from colon carcinoma five years after surgery, and was successfully treated by splenectomy. We also review the scant literature experience discussing clinical diagnosis and approaches to this uncommon event.

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References

References1. Berge T. Splenic metastases. Frequencies and patterns. Acta Pathol Microbiol Scand [A] 1974;82:499–506.BergeTSplenic metastases. Frequencies and patterns.Acta Pathol Microbiol Scand [A]197482499-5062. Dunbar WH, Beahrs OH, Morlock CG. Solitary splenic metastasis incidental to rectal carcinoma: report of a case. Mayo Clin Proc 1969;44:40–45.DunbarWH]]BeahrsOH]]MorlockCGSolitary splenic metastasis incidental to rectal carcinoma: report of a case.Mayo Clin Proc19694440-453. Waller RM III, Fajman WA. An unusual cause of an isolated, focal splenic defect demonstrated by liver-spleen scintigraphy. Clin Nucl Med 1982;7:5–7.WallerRMIII]]FajmanWAAn unusual cause of an isolated, focal splenic defect demonstrated by liver-spleen scintigraphy.Clin Nucl Med198275-74. Slavin JD Jr, Matthews J, Spencer RP. Splenectomy for splenic metastasis from carcinoma of the colon. Clin Nucl Med 1986;11:491–492.SlavinJDJr]]MatthewsJ]]SpencerRPSplenectomy for splenic metastasis from carcinoma of the colon.Clin Nucl Med198611491-4925. Capizzi PJ, Allen KB, Amerson JR, et al. Isolated splenic metastasis from rectal carcinoma. South Med J 1992;85:1003–1005.CapizziPJ]]AllenKB]]AmersonJR&etal;Isolated splenic metastasis from rectal carcinoma.South Med J1992851003-10056. Thomas SM, Fitzgerald JB, Pollock RE, et al. Isolated splenic metastases from colon carcinoma. Eur J Surg Oncol 1993;19:485–490.ThomasSM]]FitzgeraldJB]]PollockRE&etal;Isolated splenic metastases from colon carcinoma.Eur J Surg Oncol199319485-4907. Indudhara R, Vogt D, Levin HS, et al. Isolated splenic metastases from colon cancer. South Med J 1997;90:633–636.IndudharaR]]VogtD]]LevinHS&etal;Isolated splenic metastases from colon cancer.South Med J199790633-6368. Mainprize KS, Berry AR. Solitary splenic metastasis from colorectal carcinoma. Br J Surg 1997;84:70.MainprizeKS]]BerryARSolitary splenic metastasis from colorectal carcinoma.Br J Surg199784709. Weathers BK, Modesto VL, Gordon D. Isolated splenic metastasis from colorectal carcinoma: report of a case and review of the literature. Dis Colon Rectum 1999;42:1345–1348.WeathersBK]]ModestoVL]]GordonDIsolated splenic metastasis from colorectal carcinoma: report of a case and review of the literature.Dis Colon Rectum1999421345-134810. Kim JC, Jeong CS, Kim HC, et al. Isolated splenic metastasis from colorectal carcinoma: a case report. J Korean Med Sci 2000;15:355–358.KimJC]]JeongCS]]KimHC&etal;Isolated splenic metastasis from colorectal carcinoma: a case report.J Korean Med Sci200015355-35811. Place RJ. Isolated colon cancer metastasis to the spleen. Am Surg 2001;67:454–457.PlaceRJIsolated colon cancer metastasis to the spleen.Am Surg200167454-45712. Okuyama T, Oya M, Ishikawa H. Isolated splenic metastasis of sigmoid colon cancer: a case report. Jpn J Clin Oncol 2001;31:341–345.OkuyamaT]]OyaM]]IshikawaHIsolated splenic metastasis of sigmoid colon cancer: a case report.Jpn J Clin Oncol200131341-34513. Genna M, Leopardi F, Valloncini E, et al. Metachronous splenic metastasis of colon cancer. A case report. Minerva Chir 2003;58:811–814.GennaM]]LeopardiF]]VallonciniE&etal;Metachronous splenic metastasis of colon cancer. A case report.Minerva Chir200358811-81414. Cavallaro A, Modugno P, Specchia M, et al. Isolated splenic metastasis from colon cancer. J Exp Clin Cancer Res 2004;23:143–146.CavallaroA]]ModugnoP]]SpecchiaM&etal;Isolated splenic metastasis from colon cancer.J Exp Clin Cancer Res200423143-14615. Gencosmanoglu R, Aker F, Kir G, et al. Isolated metachronous splenic metastasis from synchronous colon cancer. World J Surg Oncol 2006;4:42.GencosmanogluR]]AkerF]]KirG&etal;Isolated metachronous splenic metastasis from synchronous colon cancer.World J Surg Oncol200644216. Montemurro S, Maselli E, Ruggieri E, et al. Isolated splenic metastasis from colon cancer. Report of a case. Tumori 2008;94:422–425.MontemurroS]]MaselliE]]RuggieriE&etal;Isolated splenic metastasis from colon cancer. Report of a case.Tumori200894422-42517. Skandalakis LJ, Gray SW, Skandalakis JE. Splenic realities and curiosities. Prob Gen Surg 1990;7:28–32.SkandalakisLJ]]GraySW]]SkandalakisJESplenic realities and curiosities.Prob Gen Surg1990728-3218. Nicolson GL. Cancer metastasis: tumor cell and host organ properties important in metastasis to specific secondary sites. Biochem Biophys Acta 1988;948:175–224.NicolsonGLCancer metastasis: tumor cell and host organ properties important in metastasis to specific secondary sites.Biochem Biophys Acta1988948175-224