Journal of the American Academy of Child & Adolescent Psychiatry
ARTICLESImpact of Adversity on Functioning and Comorbidity in Children with Attention-Deficit Hyperactivity Disorder
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2017, Neurotoxicology and TeratologyCitation Excerpt :The behavioral phenotype of ADHD is variable but characteristics fall broadly into two categories - inattention, and impulsivity plus hyperactivity (DSM-V, 2013); with the prevalence for the inattentive subtype potentially being as high as 5% (Wolraich et al., 1996) during childhood and 1.3% during adulthood (Murphy and Barkley, 1996). ADHD is a highly heritable disorder (Faraone and Doyle, 2000; Thapar et al., 2005) but a number of environmental factors have been proposed as contributors to the disorder, including early exposure to nicotine and alcohol (Biederman et al., 1995a; Biederman et al., 1995b). Developmental exposure to general anesthetic agents has been shown to trigger apoptotic neurodegeneration in animal models (Ikonomidou et al., 2000; Jevtovic-Todorovic et al., 2003), and this has been proposed as a mechanism for resulting behavioral impairments.
Preparation for this article was supported in part by grant R01 MH-41314-01A2 from the NIMH (USPHS) (Dr. Biederman).