| Accession Number | <strong>00003072-199811000-00017</strong>. |
|---|---|
| Author | YOUNG, TON-HO M.D. *++; CHAO, YOU-CHEN M.D. *; TANG, HUNG-SHUNG M.D. ++; HUANG, WEN-SHENG M.D. + |
| Institution | From the Division of Gastroenterology, Departments of Internal Medicine* and Nuclear Medicine,+ Tri-Service General Hospital, National Defense Medical Center, Cardinal Tien Hospital,++ Taipei, Taiwan, Republic of China |
| Title | |
| Source | Clinical Nuclear Medicine. 23(11):780-781, November 1998. |
| Abstract | Crigler-Najjar syndrome type 2 is an inherited form of hyperbilirubinemia characterized by decreased formation of conjugated bilirubin resulting in increased total serum bilirubin, mostly of the unconjugated form. Tc-99m DISIDA imaging in a 20-year-old man with Crigler-Najjar syndrome type 2 showed good liver uptake with unimpaired excretion and persistent radionuclide accumulation in the gallbladder region up to 6 hours after injection. The intrahepatic and extrahepatic biliary tree and gallbladder were seen clearly at 15 minutes. Some activity could be detected in the intestines at 2 hours. The use of radioactive dyes such as Tc-99m DISIDA help us to understand the pathophysiologic nature of this disease. To the best of our knowledge, this is the first report of Tc-99m DISIDA cholescintigraphy in Crigler-Najjar syndrome type 2. (C) 1998 Lippincott Williams & Wilkins, Inc. |