Case ReportsAntineutrophil Cytoplasmic Autoantibody-Associated Rapidly Progressive Glomerulonephritis in a Patient with Primary Biliary Cirrhosis
Section snippets
Case Report
A 66-year-old woman was admitted to the hospital on February 1996 because of general fatigue and continued low-grade fever. She had been healthy until these symptoms occurred. On examination, her blood pressure was 110/76 mm Hg, heart rate was 66 beats/min, and respiratory rate was 18 breaths/min. Findings of lung and heart examinations were normal. Findings of abdominal examination were normal (the liver was not palpable), and there was no ascites. The patient’s serum protein level was 6.4 g/dL,
Discussion
The diagnosis of PBC is based on clinical features, the cholestatic pattern in liver function test findings, and the presence of antimitochondria antibody in 90% of the cases and other autoantibodies in the serum. The diagnosis is further supported by characteristic hepatic histopathologic findings.3 The pathogenesis of PBC is still unclear. A number of studies have failed to provide direct evidence of chronic infections associated with PBC. Recently, Leung et al11 reported that chlamydial
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