Abstract
A 3-(3-(4-hydroxy-3-methylphenyl)acryloyl) coumarin has been synthesized from 4-hydroxy-3-methylbenzaldehyde with 3-acetylcoumarin. This research includes the synthesis of 4-hydroxy-3-metilbenzaldehid from ortho-cresol through Reimer-Tiemann reaction, synthesis of 3-acetylcoumarin from salicylaldehyde, synthesis of 3-(3-(4-hydroxy-3-methylphenyl)acryloyl)coumarin, and antibacterial activity testing of 3-(3-(4-hydroxy-3-methylphenyl)acryloyl)coumarin compound against Escherichia coli (gram negative bacteria) and Staphylococcus aureus (gram positive bacteria) using the disc diffusion method. The result of Reimer-Tiemann reaction was obtained as a yellow solid of 4-hydroxy-3-methylbenzaldehyde with yield of 31.91%. The synthesis of 3-acetylcoumarin was obtained as a yellow solid with a yield of 95.57%. A 3-(3-(4-hydroxy-3-methylphenyl)acryloyl)coumarin was obtained as a brownish yellow solids with yield of 11.66%. A 3-(3-(4-hydroxy-3-methylphenyl)acryloyl) coumarin has better antibacterial activity than 3-acetylcoumarin compound against Escherichia coli and Staphylococcus aureus.
Export citation and abstract BibTeX RIS
Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.