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Synthesis 4-Piperoilmorpholine from Piperine

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Published under licence by IOP Publishing Ltd
, , Citation S Bahri et al 2019 J. Phys.: Conf. Ser. 1338 012010 DOI 10.1088/1742-6596/1338/1/012010

1742-6596/1338/1/012010

Abstract

Piperine was isolated from black pepper by soxhletation method using technical grade ethanol as a solvent. This compound was used as precursor for the synthesis of 4-piperoilmorpholine. The synthesis was carried out via a pre-target piperoilchloride, where the piperine was initially hydrolyzed using KOH ethanolate for 24 hours, added SOCl2 and then mixed with morpholine at 0-5° C. The result of synthesis was obtained 4-piperoilmorpholine with yield of 40,80%.

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