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A Cost Comparison Analysis for Screening and Vaccination of Hospital Personnel with High- and Low-Prevalence Hepatitis B Virus Antibodies in California

Published online by Cambridge University Press:  09 April 2017

Myron J. Tong ,
Ruth L. Co ,
Robin D. Marci ,
Phyllis M. Michaelson  and
George Ortega
Myron J. Tong*
Affiliation:
The Liver Center, Huntington Memorial Hospital, Pasadena French Hospital, Los Angeles The Chinese Hospital
Ruth L. Co
Affiliation:
The Liver Center, Huntington Memorial Hospital, Pasadena French Hospital, Los Angeles The Chinese Hospital
Robin D. Marci
Affiliation:
The Liver Center, Huntington Memorial Hospital, Pasadena French Hospital, Los Angeles The Chinese Hospital
Phyllis M. Michaelson
Affiliation:
The Liver Center, Huntington Memorial Hospital, Pasadena French Hospital, Los Angeles The Chinese Hospital
George Ortega
Affiliation:
The Liver Center, Huntington Memorial Hospital, Pasadena French Hospital, Los Angeles The Chinese Hospital
*
Liver Center, Huntington Memorial Hospital, Pasadena, CA 91105
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Abstract

We compared the cost of antibody screening and the projected cost for hepatitis B vaccination of antibody-negative individuals at hospitals with “high prevalence” and “low prevalence” rates for hepatitis B virus antibodies among their employees. The use of hepatitis B core antibody for screening and subsequent hepatitis B vaccination of antibody-negative personnel was most cost-effective for hospitals considered to have high prevalence for hepatitis B virus antibodies among its staff, although use of hepatitis B surface antibody in this setting only increased costs by 1.4%. In a hospital with low prevalence for hepatitis B virus antibodies among its staff, use of hepatitis B surface antibody and subsequent vaccination of antibody-negative individuals was the most cost-effective approach, while use of hepatitis B core antibody for the above purposes would have increased costs by 3.4%. The use of both hepatitis B surface antibody and core antibody in either setting followed by immunization was least economical, as costs were increased by 13% and 13.5% respectively.

We concluded that hepatitis B core antibody should be used for screening in hospitals with high prevalence for hepatitis B virus antibodies among employees while hepatitis B surface antibody be used for screening in hospitals with low prevalence for hepatitis B virus antibodies among employees. A prediction of high and low prevalence for hepatitis B virus antibodies in hospital personnel may be made by knowledge of the distribution in ethnicity of staff.

Type
Original Articles
Information
Infection Control & Hospital Epidemiology , Volume 9 , Issue 2 , February 1988 , pp. 66 - 71
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1998

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