Prolonged T1 Relaxation of the Hemopoietic Bone Marrow in Patients with Chronic Leukemia

K. E. Jensen Departments of Magnetic Resonance, Hematology and Pathology, Hvidovre Hospital, University of Copenhagen, Denmark; Department of Hematology, Gentofte Hospital, University of Copenhagen, Denmark

P. G. Sørensen Departments of Magnetic Resonance, Hematology and Pathology, Hvidovre Hospital, University of Copenhagen, Denmark; Department of Hematology, Gentofte Hospital, University of Copenhagen, Denmark

C. Thomsen Departments of Magnetic Resonance, Hematology and Pathology, Hvidovre Hospital, University of Copenhagen, Denmark; Department of Hematology, Gentofte Hospital, University of Copenhagen, Denmark

P. Christoffersen Departments of Magnetic Resonance, Hematology and Pathology, Hvidovre Hospital, University of Copenhagen, Denmark; Department of Hematology, Gentofte Hospital, University of Copenhagen, Denmark

O. Henriksen Departments of Magnetic Resonance, Hematology and Pathology, Hvidovre Hospital, University of Copenhagen, Denmark; Department of Hematology, Gentofte Hospital, University of Copenhagen, Denmark

H. Karle Departments of Magnetic Resonance, Hematology and Pathology, Hvidovre Hospital, University of Copenhagen, Denmark; Department of Hematology, Gentofte Hospital, University of Copenhagen, Denmark

Abstract

Eleven patients with chronic leukemia (7 with chronic lymphocytic leukemia and 4 with chronic myeloid leukemia) were evaluated with magnetic resonance (MR) imaging and T1 relaxation time measurements by use of a 1.5 tesla whole body MR scanner. Bone marrow biopsies were obtained from the posterior iliac crest (within 72 hours of the MR examination) in order to provide data on bone marrow cellularity and differential counts. The patients with chronic leukemia all showed a significant prolongation of the T1 relaxation times compared with the normal range for hemopoietic bone marrow.

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Prolonged T1 Relaxation of the Hemopoietic Bone Marrow in Patients with Chronic Leukemia

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Prolonged T1 Relaxation of the Hemopoietic Bone Marrow in Patients with Chronic Leukemia

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