The role of cell cycle regulatory proteins in the pathogenesis of melanoma
References (211)
- et al.
Cutaneous melanoma
Lancet
(2005) - et al.
Spitz naevus versus Spitzoid melanoma: when and how can they be distinguished? (See comment.)
Pathology
(2002) - et al.
Correlations of cell cycle regulators (p53, p21, pRb and mdm2) and c-erbB-2 with biological markers of proliferation and overall survival in breast cancer
Pathology
(2005) Cell cycle checkpoints
Curr Opin Cell Biol
(1994)- et al.
Progression in cutaneous malignant melanoma is associated with distinct expression profiles: a tissue microarray-based study
Am J Pathol
(2004) - et al.
Cyclin D-dependent kinases, INK4 inhibitors and cancer
Biochim Biophys Acta
(2002) The retinoblastoma protein and cell cycle control
Cell
(1995)- et al.
Genetic testing for melanoma
Lancet Oncol
(2002) - et al.
Mutations in the INK4a/ARF melanoma susceptibility locus functionally impair p14ARF
J Biol Chem
(2001) - et al.
Expression and localization of mutant p16 proteins in melanocytic lesions from familial melanoma patients
Hum Pathol
(2004)
Cyclin-dependent kinase (cdk6) and p16 in pancreatic endocrine neoplasms
Pathology
Expression of the tumor suppressor gene product p 16INK4 in benign and malignant melanocytic lesions
J Invest Dermatol
An analysis of p16 tumour suppressor gene expression in acral lentiginous melanoma
Br J Plastic Surg
The retinoblastoma protein pathway and the restriction point
Curr Opin Cell Biol
Cyclin A is required for the onset of DNA replication in mammalian fibroblasts
Cell
DNA amplification at 11q13 in human cancer: from complexity to perplexity
Mutat Res
Altered expression of Rb and p53 in uveal melanomas following plaque radiotherapy
Am J Ophthalmol
(accessed May)
(accessed May)
Cancer in New South Wales: incidence and Mortality 2003
The pathogenesis of melanoma induced by ultraviolet radiation. (See comment.)
New Engl J Med
The cell cycle of mammalian cells
Int Rev Exp Pathol
Animal cell cycles and their control
Ann Rev Biochem
Cell cycle control and cancer
Science
Cell cycle regulators: mechanisms and their role in aetiology, prognosis, and treatment of cancer
J Clin Pathol
Mammalian cell fusion: studies on the regulation of DNA synthesis and mitosis
Nature
Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes
J Exp Zool
Coordinating cell cycle events
Cold Spring Harbor Symposia on Quantitative Biology
Cancer p53, guardian of the genome. (See comment.)
Nature
Analysis of G(1)/S checkpoint regulators in metastatic melanoma
Genes Chromosomes Cancer
The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis
Cancer Res
CDKN2A/p16 is inactivated in most melanoma cell lines
Cancer Res
Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets
Genes Chromosomes Cancer
CDK inhibitors: positive and negative regulators of G1-phase progression
Genes Devel
Rarity of somatic and germline mutations of the cyclin-dependent kinase 4 inhibitor gene, CDK4I, in melanoma
Cancer Res
Abnormalities in the CDKN2 (p16INK4/MTS-1) gene in human melanoma cells: relevance to tumor growth and metastasis
Oncogene
Multiple abnormalities of the p16INK4a-pRb regulatory pathway in cultured melanoma cells
Melanoma Res
Genetic evidence in melanoma and bladder cancers that p16 and p53 function in separate pathways of tumor suppression
Am J Pathol
Deletion mapping of chromosome region 9p21-p22 surrounding the CDKN2 locus in melanoma
Int J Cancer
Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas
Br J Cancer
Mutations in the CDKN2A (p16INK4a) gene in microdissected sporadic primary melanomas
Int J Cancer
Homozygous deletion of the p16INK4a and the p15INK4b tumour suppressor genes in a subset of human sporadic cutaneous malignant melanoma
Br J Dermatol
Mutations of p16 and p15 tumor suppressor genes and replication errors contribute independently to the pathogenesis of sporadic malignant melanoma
Arch Dermatol Res
A melanoma-associated germline mutation in exon 1beta inactivates p14ARF
Oncogene
Germline p16 mutations in familial melanoma. (See comment.)
Nature Genet
CDKN2A variants in a population- based sample of Queensland families with melanoma
J Natl Cancer Inst
Loss of heterozygosity of tumor suppressor genes in testis cancer
Cancer Res
p16INK4a expression is frequently decreased and associated with 9p21 loss of heterozygosity in sporadic melanoma
J Cut Pathol
Loss of the p16INK4a and p15INK4b genes, as well as neighboring 9p21 markers, in sporadic melanoma
Cancer Res
CDKN2A (p16INK4A) somatic and germline mutations
Hum Mutat
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2020, Seminars in Cancer BiologyCitation Excerpt :Cyclin D1 is a direct target of mitogenic signaling cascades including epidermal growth factor receptor (EGFR) [12,13], and phosphatidylinositol 3-kinase (PI3K)-Akt [14–16], and it is sensitive to transcription factors such as β-Catenin [17,18], and nuclear factor-kappa B (NF-κB) [19,20]. In addition, the CCND1 gene is amplified in a variety of human cancers including pancreatic cancer [21], non-small cell lung carcinoma (NSCLC) [22–24], breast cancer [25], head and neck squamous cell carcinoma (HNSCC) [26,27], melanoma [28], endometrial cancer [29,30], esophageal squamous cell carcinoma (ESCC) [31,32], and colorectal carcinoma [7] (Table 1). CCND1 is dysregulated via chromosome translocation in mantle cell lymphoma (MCL) and multiple myeloma [33,34].
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