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Carrageenan-induced granuloma and iron status in rats with dietary polyunsaturated fatty acid deficiency

Published online by Cambridge University Press:  09 March 2007

T. Carbonell ,
M. P. Saiz ,
M. T. Mitjavila ,
P. Puig-Parellada ,
C. Cambon-Gros ,
Y. Fernandez  and
S. Mitjavila
T. Carbonell
Affiliation:
Departamento de Bioquimica y Fisiologia, Facultad de Biologia, Universidad de Barcelona, Avenida Diagonal 645, E-08071-Barcelona, Spain
M. P. Saiz
Affiliation:
Departamento de Bioquimica y Fisiologia, Facultad de Biologia, Universidad de Barcelona, Avenida Diagonal 645, E-08071-Barcelona, Spain
M. T. Mitjavila
Affiliation:
Departamento de Bioquimica y Fisiologia, Facultad de Biologia, Universidad de Barcelona, Avenida Diagonal 645, E-08071-Barcelona, Spain
P. Puig-Parellada
Affiliation:
Departamento de Farmacologia, Facultad de Medicina, Universidad de Barcelona, E-08028-Barcelona, Spain
C. Cambon-Gros
Affiliation:
Université Paul Sabatier, Institut de Physiologie, INSERM U-87, 31400-Toulouse, France
Y. Fernandez
Affiliation:
Université Paul Sabatier, Institut de Physiologie, INSERM U-87, 31400-Toulouse, France
S. Mitjavila
Affiliation:
Université Paul Sabatier, Institut de Physiologie, INSERM U-87, 31400-Toulouse, France
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Abstract

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Sprague–Dawley rats were fed for 4 months on a control diet or a polyunsaturated-fatty-acid (PUFA)-deficient diet. The combined effects of iron overload (Fe dextran) or Fe deficiency (desferrioxamine) on carrageenan-induced granuloma were studied. PUFA deficiency induced changes in Fe metabolism, but no alterations in lipid peroxidation variables were observed. Inflammation implied an increase in lipid peroxidation, Fe storage and caeruloplasmin concentration, together with symptoms of anaemia. PUFA deficiency in inflamed rats gave rise to a lower inflammatory response (granuloma weight and prostaglandin E2 concentration) and ethane exhalation. Fe overload potentiated inflammatory and lipid peroxidation processes, whereas Fe deficiency decreased them.

Keywords

Iron statusCarrageenan-induced granulomaRat
Type
Effects of Fatty Acid Deficiency
Information
British Journal of Nutrition , Volume 65 , Issue 3 , May 1991 , pp. 497 - 503
Copyright
Copyright © The Nutrition Society 1991

References

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