Hostname: page-component-848d4c4894-pftt2 Total loading time: 0 Render date: 2024-06-06T23:40:52.826Z Has data issue: false hasContentIssue false
  • English
  • Français

Glucose tolerance and insulin sensitivity in malnourished children

Published online by Cambridge University Press:  09 March 2007

G. A. O. Alleyne ,
P. M. Trust ,
H. Flores  and
H. Robinson
G. A. O. Alleyne
Affiliation:
Tropical Metabolism Research Unit, University of the West Indies, Mona, Kingston 7, Jamaica, WI
P. M. Trust
Affiliation:
Tropical Metabolism Research Unit, University of the West Indies, Mona, Kingston 7, Jamaica, WI
H. Flores
Affiliation:
Tropical Metabolism Research Unit, University of the West Indies, Mona, Kingston 7, Jamaica, WI
H. Robinson
Affiliation:
Tropical Metabolism Research Unit, University of the West Indies, Mona, Kingston 7, Jamaica, WI
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. In malnourished, compared with recovered children, fasting blood glucose concentrations were low and there was impaired peripheral glycolysis as shown by a failure of blood lactate to rise after glucose was injected intravenously.

2. Homogenates of muscle biopsies from malnourished and recovered children produced equal amounts of lactate when incubated anaerobically with various substrates, but when compared with homogenates of biopsies from normal children the pattern suggested an impairment of glycolysis.

3. The rate of glucose disappearance after intravenous glucose was slow in the malnourished child and there was possibly diminished sensitivity to exogenous insulin.

4. Isocaloric diets relatively high or low in fat were fed to children who had recovered from malnutrition. Glucose tolerance, insulin sensitivity, fasting plasma insulin and insulin response to intravenous glucose were all the same in children on either diet.

Type
Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 27 , Issue 3 , May 1972 , pp. 585 - 592
Copyright
Copyright © The Nutrition Society 1972

References

Alleyne, G. A. O. (1970). W. Indian med. J. 19, 32.Google Scholar
Alleyne, G. A. O., Flores, H., Trust, P. M. & Waterlow, J. C.. (1970). J. Physiol., Lond. 213, 30P.Google Scholar
Alleyne, G. A. O., Millward, D. J. & Scullard, G. H. (1970). J. Pediat. 76, 75.CrossRefGoogle Scholar
Baig, H. A. & Edozien, J. C. (1965). Lancet ii, 662.CrossRefGoogle Scholar
Bergmeyer, H. U. (1965). Methods of Enzymatic Analysis. New York: Academic Press.Google Scholar
Blizquez, E. & Lopez Quijada, E. (1968). J. Endocr. 42, 489.CrossRefGoogle Scholar
Bras, G., Waterlow, J. C. & DePass, E. (1956). J. trop. Pediat. 2, 147.CrossRefGoogle Scholar
Cook, G. G. (1967). Nature, Lond. 215, 1295.CrossRefGoogle Scholar
Davies, J. N. P. (1948). Lancet i, 317.CrossRefGoogle Scholar
Garrow, J. S. (1965). Lancet ii, 455.CrossRefGoogle Scholar
Gillman, J. & Gillman, T. (1951). Perspectives in Humara Malnutrition. New York; Grune and Stratton.Google Scholar
Graham, C. G., Cordano, A., Blizzard, R. M. & Cheek, D. B. (1969). Pediat. Res. 3, 579.CrossRefGoogle Scholar
Hadden, D. R. (1967). Lancet ii, 589.CrossRefGoogle Scholar
Hansen, J. D. L. (1956). S. Afr. J. Lab. clin. Med. 2, 206.Google Scholar
Heard, C. R. C. & Henry, P. A. J. (1969). Clin. Sci. 37, 37-Google Scholar
Heard, C. R. C. & Turner, M. R. (1967). Diabetes 16, 96.CrossRefGoogle Scholar
Huggett, A. S. G. & Nixon, D. A. (1957). Lancet ii, 368.CrossRefGoogle Scholar
James, W. P. T. & Coore, G. H. (1970). Am. J. clin. Nutr. 23, 386.CrossRefGoogle Scholar
Layzer, R. B., Rowland, L. P. & Ranney, H. M. (1967). Archs Neurol., Chicago 17, 512.CrossRefGoogle Scholar
Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951). J. biol. Chem. 193, 265.CrossRefGoogle Scholar
Metcoff, J., Frenk, S., Yoshida, T., Pinedo, R. T., Kaiser, E. & Hansen, J. D. L. (1966). Medicine, Baltimore 45, 365.CrossRefGoogle Scholar
Milner, R. D. G. (1971). Pediat. Res. 5, 33.CrossRefGoogle Scholar
Mondon, C. E., Burton, S. D., Grodsky, G. NI. & Ishida, T. (1968). Am. J. Physiol. 215, 779.CrossRefGoogle Scholar
Nelson, W. E. (1959). Textbook of Pediatrics. Philadelphia and London: W. B. Saunders Co.Google Scholar
Nichols, B. L., Alleyne, G. A. O., Barnes, D. J. & Hazlewood, C. F. (1969). Pediatrics, Springfield 74, 49.Google Scholar
Nichols, B. L., Hazlewood, C. F. & Barnes, D. J. (1968). J. Pediat. 72, 840.CrossRefGoogle Scholar
Oxman, S. V., Maccioni, A. S., Zuniga, A. C., Spada, R. G. & Monckeberg, F. R. (1968). Am. J. clin. Nutr. 21, 1285.Google Scholar
Saglid, U., Andersen, V. & Andreasen, P. B. (1961). Act. med. scund. 169, 243.CrossRefGoogle Scholar
Sloane, D., Taitz, L. S. & Gilchrist, G. S. (1961). Br. med. J. 1, 32.CrossRefGoogle Scholar
Waterlow, J. C., Cravioto, J. & Stephen, J. M. L. (1960). Adv. Protein. Chem. 15, 131.CrossRefGoogle Scholar
Waterlow, J. C. & Mendes, C. B. (1957). Nature, Lond. 180, 1361.CrossRefGoogle Scholar
Zaragoza, N. & Felber, J. P. (1970). Horm. Metab. Res. 2, 323.CrossRefGoogle Scholar