Hostname: page-component-848d4c4894-5nwft Total loading time: 0 Render date: 2024-05-28T23:06:41.465Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of protein restriction on messenger RNA of insulin-like growth factor-I and insulin-like growth factor-binding proteins in liver of ovariectomized rats

Published online by Cambridge University Press:  09 March 2007

Yusuke Higashi ,
Asako Takenaka ,
Shin-Ichiro Takahashi  and
Tadashi Noguchi
Yusuke Higashi
Affiliation:
Laboratory of Nutritional Biochemistry, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyoku, Tokyo 113, Japan
Asako Takenaka
Affiliation:
Laboratory of Nutritional Biochemistry, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyoku, Tokyo 113, Japan
Shin-Ichiro Takahashi
Affiliation:
Laboratory of Nutritional Biochemistry, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyoku, Tokyo 113, Japan
Tadashi Noguchi*
Affiliation:
Laboratory of Nutritional Biochemistry, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyoku, Tokyo 113, Japan
*
§Corresponding author: Dr Tadashi Noguchi, fax +81 3 3812 0544, email noguchi@eiyo.m.u-tokyo.ac.jp
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Effects of dietary protein restriction and ovariectomy on plasma concentrations and hepatic messenger RNA (mRNA) of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding proteins (IGFBP) were investigated in young female rats. Ovariectomy increased plasma IGF-I concentration in rats fed on either a 50 g casein/kg diet (protein-restricted diet) or a 200 g casein/kg diet (control diet), but it increased IGF-I mRNA in liver only in the rats fed on the control diet. On the other hand, by Western ligand blot analysis, we observed that ovariectomy increased plasma IGFBP-3 concentration, and decreased plasma IGFBP-4 concentration. Ovariectomy did not affect IGFBP-1 and IGFBP-2 mRNA in liver, but dietary protein restriction significantly increased them, which may correspond to their plasma concentrations. The present results show that ovarian hormones and dietary protein content affect the plasma concentrations of IGF-I, IGFBP-3 and IGFBP-4 and hepatic mRNA of IGF-I, IGFBP-1, IGFBP-2, IGFBP-3 and IGFBP-4 in different manners.

Keywords

Insulin-like growth factor-IInsulin-like growth factor-binding proteinsProtein restrictionOvariectomy
Type
General Nutrition
Information
British Journal of Nutrition , Volume 79 , Issue 5 , May 1998 , pp. 447 - 453
Copyright
Copyright © The Nutrition Society 1998

References

Aerssens, J, Audekercke, RV, Geusens, P, Schot, LPC, Osman, AAH & Dequeker, J (1993) Mechanical properties, bone mineral content, and bone composition (collagen, osteocalcin, IGF-I) of the rat femur: influence of ovariectomy and nandrolone decanoate (anabolic steroid) treatment. Calcified Tissue International 53, 269–277.CrossRefGoogle ScholarPubMed
Baylink, DJ, Finkelman, RD & Mohan, S (1993) Growth factors to stimulate bone formation. Journal of Bone and Mineral Research 8, S565–S572.CrossRefGoogle ScholarPubMed
Brinkman, A, Goffen, G, Kortleve, DJ, Geurts, van, Kessel, A & Drop, SLA (1988) Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1). EMBO Journal 7, 2417–2423.CrossRefGoogle ScholarPubMed
Brown, AL, Chiarotti, L & Orlowski, CC (1989) Nucleotide sequence and expression of a cDNA close encoding a fetal rat binding protein for insulin-like growth factors. Journal of Biological Chemistry 264, 5148–5154.CrossRefGoogle ScholarPubMed
Cohen, KL & Nissley, SP (1975) Comparison of somatomedin activity in rat serum and lymph. Endocrinology 97 654–658.CrossRefGoogle ScholarPubMed
Crawford, BA, Martin, JL, Howe, CJ, Handelsman, DJ & Baxter, RC (1992) Comparison of extraction methods for insulin-like growth factor-I in rat serum. Journal of Endocrinology 134 169–176.CrossRefGoogle ScholarPubMed
Hammond, JM, Samaras, SE, Grimes, R, Leighton, J, Barber, J, Canning, SF & Guthirie, HD (1993) The role of insulin-like growth factors and epidermal growth factor-related peptides in intraovarian regulation in the pig ovary. Journal of Reproduction and Fertility 48, Suppl., 117–125.Google ScholarPubMed
Higashi, Y, Takenaka, A, Takahashi, S-I & Noguchi, T (1996) Effect of protein restriction on the messenger RNA contents of bone-matrix proteins, insulin-like growth factors and insulin-like growth factor binding proteins in femur of ovariectomized rats. British Journal of Nutrition 75, 811–823.CrossRefGoogle ScholarPubMed
Hinz, RL & Liu, F (1977) Demonstration of specific plasma protein binding sites for somatomedin. Journal of Clinical Endocrinology and Metabolism 45, 988–995.CrossRefGoogle Scholar
Isley, WL, Underwood, LE & Clemmons, DR (1983) Dietary components that regulate serum somatomedin-C concentrations in humans. Journal of Clinical Investigation 71, 175–182.CrossRefGoogle ScholarPubMed
Jones, JI & Clemmons, DR (1995) Insulin-like growth factors and their binding proteins: biological actions. Endocrine Reviews 16, 3–33.Google ScholarPubMed
Kalu, DU, Arijmandi, BH, Liu, C-C, Salih, MA & Birnbaum, RS (1994) Effects of ovariectomy and estrogen on the serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3. Bone and Mineral 25, 135–148.CrossRefGoogle ScholarPubMed
Kato, H, Takenaka, A, Miura, Y, Nishiyama, M & Noguchi, T (1990) Evidence of introduction by molecular cloning of artificial inverted sequence at the 5′ terminus of the sense strand of rat insulin-like growth factor-I cDNA. Agricultural Biological Chemistry 54, 2225–2230.Google ScholarPubMed
Krattenmacher, R, Knauthe, R, Parczyk, K, Walker, A, Hilgenfeldt, U & Fritzemeier, KH (1994) Estrogen action on hepatic synthesis of angiotensinogen and IGF-I: direct and indirect estrogen effects. Journal of Steroid Biochemistry and Molecular Biology 48, 207–214.CrossRefGoogle ScholarPubMed
Maes, M, Amand, Y, Underwood, LE, Maiter, D & Ketelslegers, JM (1988) Decreased serum insulin-like growth factor-I response to growth hormone in hypophysectomized rats fed a low protein diet: evidence for a post receptor defect. Acta Endocrinologica (Copenhagen) 117, 320–326.Google Scholar
Martin, JL & Baxter, RC (1986) Insulin-like growth factor-binding protein from human plasma. Purification and characterization. Journal of Biological Chemistry 261, 8754–8760.CrossRefGoogle ScholarPubMed
Miura, Y, Kato, H & Noguchi, T (1992) Effects of dietary proteins on insulin-like growth factor-I (IGF-I) messenger ribonucleic acid content in rat liver. British Journal of Nutrition 67, 257–265.CrossRefGoogle ScholarPubMed
Moats-Staats, BM, Brady, JL Jr, Underwood, LE & D'Ercole, AJ (1989) Dietary protein restriction in artificially reared neonatal rats causes a reduction of insulin-like growth factor-I gene expression. Endocrinology 125, 2368–2374.CrossRefGoogle ScholarPubMed
Mohan, S, Bautista, CM, Wergedal, J & Baylink, DJ (1989) Isolation of an inhibitory insulin-like growth factor (IGF) binding protein from bone cell-conditioned medium: a potential local regulator of IGF action. Proceedings of the National Academy of Sciences USA 86, 8338–8342.CrossRefGoogle ScholarPubMed
Murphy, LJ (1991) The uterine insulin-like growth factor system. In Modern Concepts of Insulin-like Growth Factors, pp. 275–284 [Spencer, EM editor]. New York, NY: Elsevier Science Publishing Co., Inc.Google Scholar
Murphy, LJ & Friesen, HG (1988) Differential effects of estrogen and growth hormone on uterine and hepatic insulin-like growth factor I gene expression in the ovariectomized hypophysectomized rat. Endocrinology 122, 325–332.CrossRefGoogle ScholarPubMed
Murphy, LJ, Seneviratne, C, Moreira, P & Reid, RE (1991) Enhanced expression of insulin-like growth factor-binding protein-I in the fasted rat: the effects of insulin and growth hormone administration. Endocrinology 128, 689–696.CrossRefGoogle ScholarPubMed
Nam, TJ, Noguchi, T, Funabiki, R, Kato, H, Miura, Y & Naito, H (1990) Correlation between the urinary excretion of acid-soluble peptides, fractional synthesis rate of whole body proteins, and plasma immunoreactive insulin-like growth factor- 1/somato-medin C concentration in the rat. British Journal of Nutrition 63, 515–520.CrossRefGoogle ScholarPubMed
Nestler, JE (1993) Regulation of the aromatase activity of human placental cytotrophoblast by insulin, insulin-like growth factor-I and -II. Journal of Steroid Biochemistry and Molecular Biology 44, 449–457.CrossRefGoogle ScholarPubMed
Orlowski, CC, Brown, AL, Ooi, GT, Yang, YW-H, Tseng, LY-H & Rechler, MM (1990) Tissue, developmental and metabolic regulation of messenger ribonucleic acid encoding a rat insulin-like growth factor-binding protein. Endocrinology 126, 644–652.CrossRefGoogle ScholarPubMed
Prewitt, TE, D'Ercole, AJ, Switzer, BR & Van Wyk, JJ (1982) Relationship of serum immunoreactive somatomedin-C to dietary protein and energy in growing rats. Journal of Nutrition 112, 144–150.CrossRefGoogle ScholarPubMed
Sato, F, Ouchi, Y, Masuyama, A, Nakamura, T, Hosoi, T, Okamoto, Y, Sasaki, N, Shiraki, M & Orimo, H (1993) Effects of estrogen replacement on insulin-like growth factor I concentrations in serum and bone tissue and on interleukin 1 secretion from spleen macrophages in oophorectomized rats. Calcified Tissue International 53, 111–116.CrossRefGoogle ScholarPubMed
Shimasaki, S, Uchiyama, F, Shimonaka, M & Ling, N (1990) Molecular cloning of the cDNAs encoding a novel insulin-like growth factor binding protein from rat and human. Molecular Endocrinology 4, 1451–1458.CrossRefGoogle ScholarPubMed
Shimasaki, S, Gao, L, Shimonaka, M & Ling, N (1991 a) Isolation and molecular cloning of insulin-like growth factor-binding protein-6. Molecular Endocrinology 5, 938–948.CrossRefGoogle ScholarPubMed
Shimasaki, S, Shimonaka, M, Zhang, H-P & Ling, N (1991 b) Identification of five different insulin-like growth factor binding-proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat plasma. Journal of Biological Chemistry 266, 10646–10653.CrossRefGoogle Scholar
Snedecor, GW & Cochran, WG (1967) One-way classifications. Analysis of variance. Inspection of all differences between pairs of means. In Statistical Methods, 6th ed., pp. 271–273. Ames, IA: Iowa State University Press.Google Scholar
Takahashi, S, Kajikawa, M, Umezawa, T, Takahashi, S-I, Kato, H, Miura, Y, Nam, TJ, Noguchi, T & Naito, H (1990) Effect of dietary proteins on the plasma immunoreactive insulin-like growth factor-1/somatomedin c concentration in the rat. British Journal of Nutrition 63, 521–534.CrossRefGoogle ScholarPubMed
Takenaka, A, Hirosawa, M, Mori, M, Yamada, S, Miura, Y, Kato, H, Takahashi, S-I & Noguchi, T (1993) Effect of protein nutrition on the mRNA content of insulin-like growth factor-binding protein-1 in liver and kidney of rats. British Journal of Nutrition 69, 73–82.CrossRefGoogle ScholarPubMed
Takenaka, A, Miura, Y, Mori, M, Hirosawa, M, Kato, H & Noguchi, T (1991) Distribution of messenger RNAs of insulin-like growth factor (IGF)-binding proteins-1 and -3 between parenchymal and nonparenchymal cells in rat liver. Agricultural and Biological Chemsitry 55, 1191–1193.Google Scholar
Takenaka, A, Mori, M, Yamada, S, Ohgane, J, Takahashi, S-I & Noguchi, T (1996) Nutritional regulation of gene expression of insulin-like growth factor-binding proteins and the acid-labile subunit in various tissues of rats. Journal of Endocrinology 150, 33–41.CrossRefGoogle ScholarPubMed
Thissen, J-P, Ketelslegers, J-M & Underwood, LE (1994) Nutritional regulation of the insulin-like growth factors. Endocrine Reviews 15, 80–101.Google Scholar
Thissen, J-P, Triest, S, Moats-Staats, BM, Underwood, LE, Mauerhoff, T, Maiter, D & Ketelslegers, JM (1991 a) Evidence that pretranslational and translational defects decrease serum IGF-I concentrations during dietary protein restriction. Endocrinology 129, 429–435.CrossRefGoogle ScholarPubMed
Thissen, J-P, Underwood, LE, Maiter, D, Maes, M, Clemmons, DR & Ketelslegers, J-M (1991 b) Failure of insulin-like growth factor-I (IGF-I) infusion to promote growth in protein-restricted rats despite normalization of serum IGF-I concentrations. Endocrinology 128, 885–890.CrossRefGoogle ScholarPubMed
Umezawa, T, Ohsawa, Y, Miura, Y, Kato, H & Noguchi, T (1991) Effect of protein deprivation on insulin-like growth factor-binding proteins in rats. British Journal of Nutrition 66, 105–116.CrossRefGoogle ScholarPubMed
Vinik, A, Pittenger, G, Rafaeloff, R & Rosenberg, L (1993) Factors controlling pancreatic islet neogenesis. Tumor Biology 14, 184–200.CrossRefGoogle ScholarPubMed