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The acute impact of ethanol on glucose, insulin, triacylglycerol, and free fatty acid responses and insulin sensitivity in type 2 diabetes

Published online by Cambridge University Press:  09 March 2007

Christian Christiansen ,
Claus Thomsen ,
Ole Rasmussen ,
Carsten Hansen  and
Kjeld Hermansen
Christian Christiansen
Affiliation:
Medical Department C (University Clinic of Diabetes and Endocrinology), Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansensgade 2, DK-8000 Aarhus C, Denmark
Claus Thomsen
Affiliation:
Medical Department C (University Clinic of Diabetes and Endocrinology), Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansensgade 2, DK-8000 Aarhus C, Denmark
Ole Rasmussen
Affiliation:
Medical Department C (University Clinic of Diabetes and Endocrinology), Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansensgade 2, DK-8000 Aarhus C, Denmark
Carsten Hansen
Affiliation:
Department of Forensic Toxicology, Aarhus University, Aarhus, Denmark
Kjeld Hermansen
Affiliation:
Medical Department C (University Clinic of Diabetes and Endocrinology), Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansensgade 2, DK-8000 Aarhus C, Denmark
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Abstract

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The aim of the present study was to evaluate the acute effect of ethanol on insulin sensitivity, and glucose, insulin, free fatty acid (FFA), and triacylglycerol responses in ten patients with non-insulin-dependent (type 2) diabetes. In the test study an oral dose of 0·66 g ethanol/kg followed by continuous intravenous infusion of 0·1 g ethanol/kg per h was given to maintain a constant ethanol level in the blood. In the control study identical volumes of oral water and intravenous saline (9 g NaCl/l) were given. After 90 min insulin sensitivity was determined by the hyperinsulinaemic, euglycaemic clamp technique. Ethanol caused no change in blood glucose or insulin concentrations. The FFA level was suppressed by ethanol while the triacylglycerol level was unaffected. The insulin sensitivity was not affected by ethanol. No major acute effect of ethanol on the glycaemic control in fasting type 2 diabetic patients was found in comparison with what is seen in healthy people. The present study, along with the sparse literature, indicates that the ability of ethanol to induce hypoglycaemia is attenuated or absent in diet-treated type 2 diabetes. Furthermore, we found no change in insulin sensitivity. Consequently, the risk of acute ethanol-induced aberrations in carbohydrate metabolism in diet-treated type 2 diabetes seems to be less than previously expected, when alcohol is not taken as a part of a meal.

Keywords

Non-insulin-dependent diabetes mellitusEthanolInsulin sensitivity
Type
Human and Clinical Nutrition
Information
British Journal of Nutrition , Volume 76 , Issue 5 , November 1996 , pp. 669 - 675
Copyright
Copyright © The Nutrition Society 1996

References

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