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A key mechanism of pathogenesis in sheep infected with the nematode Teladorsagia circumcincta

Published online by Cambridge University Press:  28 February 2007

M. J. Stear ,
S. C. Bishop ,
N. G. Henderson  and
I. Scott
M. J. Stear*
Affiliation:
Department of Veterinary Clinical Studies, Glasgow University Veterinary School, Glasgow, UK
S. C. Bishop
Affiliation:
Department of Biometrical Genetics, Roslin Institute, Roslin, UK
N. G. Henderson
Affiliation:
Department of Veterinary Clinical Studies, Glasgow University Veterinary School, Glasgow, UK
I. Scott
Affiliation:
Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand
*
*Department of Veterinary Clinical Studies, Glasgow University Veterinary School, Bearsden Road, Glasgow G61 1QH, UK E-mail: m.j.stear@vet.gla.ac.uk Fax: +44 (0)1419 427215
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Abstract

Infection of sheep with the abomasal nematode Teladorsagia circumcincta can cause a relative protein deficiency and reduce growth rate in growing lambs. A key event appears to be the destruction of junctions between epithelial cells. If the infection is heavy or prolonged, this leads to increased mucus production, hyperplasia, decreased acid production, gastrinemia, inappetance and pepsinogenemia. The severity of the infection depends upon the extent of concurrent infection, the nutritional status of the host and genetically controlled variation in the ability to mount protective immune responses.

Keywords

Teladorsagia circumcinctapathogenesissheepparasitic diseasesparasitic nematodes
Type
Research Article
Information
Animal Health Research Reviews , Volume 4 , Issue 1 , June 2003 , pp. 45 - 52
Copyright
Copyright © CAB International 2003

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