Molecular & Cellular Proteomics
Technological Innovation and ResourcesHigh Sensitivity Crosslink Detection Coupled With Integrative Structure Modeling in the Mass Spec Studio*
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Author contributions: V.S., N.O., A.B.S., and D.C.S. designed research; V.S., A.R., M.H., and D.C.S. performed research; N.O. and A.B.S. contributed new reagents or analytic tools; V.S., A.R., M.H., N.O., and D.C.S. analyzed data; V.S. and D.C.S. wrote the paper.
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The work was supported by an NSERC Discovery Grant RGPIN/298351-2010, the Canada Foundation for Innovation (DCS) and the University of Calgary.
This article contains supplemental material.
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The abbreviations used are:
- CL
covalent labeling
- BSA
bovine serum albumin
- DSS
disuccinimidyl suberate
- FDR
false discovery rate
- HX
hydrogen-deuterium exchange
- MEF
microsoft extensibility framework
- PSM
peptide spectrum match
- ppm
parts per million
- pTf
porcine transferrin
- SEC
size-exclusion chromatography
- TpbA
tranferrin-binding protein A
- TbpB
tranferrin-binding protein B
- UI
user interface
- XIC
extracted ion chromatogram
- XL
cross-linking.