Molecular & Cellular Proteomics
ResearchProteome-scale Binary Interactomics in Human Cells*
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Author contributions: S.L., J.V., D.M., L.D., I.P., S.G., L.M., K.D., C.L., and J.T. designed research; S.L., J.V., D.M., L.D., I.P., S.G., D. Defever, N.V., and A.D. performed research; V.D., V.V., I.L., D. De Clercq, S.V., L.M., D.H., and M.V. contributed new reagents or analytic tools; S.L., J.V., D.M., L.D., I.P., S.G., V.D., V.V., S.E., K.D., C.L., and J.T. analyzed data; S.L., J.V., D.M., L.D., V.D., I.L., and J.T. wrote the paper.
Financial interests: J.T. is scientific cofounder of and has financial interests in Orionis Biosciences, which practices technologies described in this publication. S.L. is an employee of Orionis Biosciences.
- *
This work was supported by grants from the Belgian government (Interuniversity Attraction Poles Project P6/36), the Fund for Scientific Research - Flanders (FWO-V Project G.0864.10) and the NIH (U01 HG001715). J.T. is the recipient of an ERC Advanced Grant (# 340941).
This article contains supplemental material.
- 1
The abbreviations used are:
- PPI
protein-protein interaction
- GRE
GR response element
- MAPPIT
mammalian protein-protein interaction trap
- MASPIT
mammalian small molecule-protein interaction trap
- MTX
methotrexate
- ORF
open reading frame
- SAR
structure-activity relationship
- TMP
trimethoprim.
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Current address: Orionis Biosciences, Ghent, Belgium.
- a
Sorbonne Universités, UPMC, INSERM, Centre de Recherche Saint-Antoine, Paris, France.
- b
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts.