Molecular & Cellular Proteomics
ResearchProfiling the Proteome of Mycobacterium tuberculosis during Dormancy and Reactivation*
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Author contributions: V.G., S.R., R.L.G., L.J., and R.A.K. designed research; V.G., S.R., L.J., A.S., R.R., A.R.P., and R.L.G. performed research; V.G., S.R., R.L.G., L.J., A.S., and A.J. contributed new reagents or analytic tools; V.G., S.R., R.L.G., L.J., R.R., A.R.P., and R.A.K. analyzed data; V.G., S.R., L.J., R.R., A.R.P., S.M., A.J., and R.A.K. wrote the paper.
Additional information: The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD001158 and DOI 10.6019/PXD001158. Supplemental data containing details such as uniquely expressed, up-regulated and down-regulated proteins, and their functional classification are available online through the MCP website.
- TB
Tuberculosis
- MTB
Mycobacterium tuberculosis
- BCG
Bacillus Calmette–Guérin
- NRP1
Nonreplicating persistent stage 1
- NRP2
Nonreplicating persistent stage 2
- R6
6 hours after Reactivation
- R24
24 hours after Reactivation
- LC/MS/MS
Liquid chromatography – tandem mass spectrometry
- GO
Gene Ontology
- DAVID
Database for Annotation, Visualization and Integrated Discovery
- PBS
Phosphate buffered saline
- MPDS
MassPREP™ Digestion Standard
- CFU
Colony forming unit.
1 The abbreviations used are:
- *
This study has been funded by the Department of Biotechnology, Government of India [BT/PR5361/MED/29/507/2012 (RAK)]. SR thanks Department of Science and Technology, Government of India, for INSPIRE fellowship. RLG and LJ acknowledge Council for Scientific and Industrial Research, Government of India, and RR acknowledges University Grants Commission, Government of India, for research fellowship. We are grateful to the PRIDE Team for assistance in MS/MS data distribution.
This article contains supplemental Lists S1 to S5.
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Vipin Gopinath and Sajith Raghunandanan have contributed equally to this work.