Journal of Biological Chemistry
Volume 294, Issue 29, 19 July 2019, Pages 11276-11285
Molecular Bases of DiseaseIndividual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cellsPresenilin 1 and 2 knockout
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open access
presenilin
inhibitor
γ-secretase
amyloid-beta (AB)
Notch protein
amyloid protein precursor
aspartyl protease
cancer
neurodegeneration
NOTCH
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This work was supported by NCI, National Institutes of Health Grant 1P01CA166009 01A1 (to B. A. O., L. M., and T. E. G.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
This article contains Tables S1–S3 and Figs. S1–S3.
© 2019 Lessard et al.