Journal of Biological Chemistry
NeurobiologyMitochondrially targeted cytochrome P450 2D6 is involved in monomethylamine-induced neuronal damage in mouse models
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This work was supported in part by National Institutes of Health Grant RO1 GM034883 and an endowment from the Harriet Ellison Woodward trust (to N. G. A.) and National Institutes of Health Grant R01 GM118122 (to F. P. G.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
This article contains Figs. S1–S3.
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Present address: Dept. of Neuroscience, University of Nevada, Reno, NV 89557-0314.
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The abbreviations used are:
- PD
Parkinson's disease
- MPTP
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- MPP+
1-methyl-4-phenylpyridinium
- CYP
cytochrome P450
- ER
endoplasmic reticulum
- Adx
adrenodoxin
- AdxR
adrenodoxin reductase
- CYPOR
cytochrome P450 reductase
- TISQ
2-methyl-1,2,3,4-tetrahydroisoquinoline
- MTHBC
2-methyl-1,2,3,4-tetrahydro-β-carboline
- β-Carb
9-methyl-9H-pyrido(3,4-β)indole
- TH
tyrosine hydroxylase
- cDNA
complementary DNA
- MAMC
7-methoxy-4-(aminomethyl) coumarin
- OCR
oxygen consumption rate.