Journal of Biological Chemistry
Molecular Bases of DiseaseParkinson's disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics
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This work was supported by National Institutes of Health Grants R01GM111639 and R01GM115844 and the Michael J. Fox Foundation(to Q. Q. H.), Grant R01GM111695 and U.S. National Science Foundation Grant MCB-1157688 (to Y. T.), the Intramural Research Program of the National Institutes of Health, National Institute on Aging (to M. R. C.), National Institutes of Health Grant R01GM120350 (to S. M. J.), and funding from the Travel and Learn program of the Indiana Association of Chinese-Americans (IACA) (to N. C. H.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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Both authors contributed equally to this work.
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The abbreviations used are:
- LRRK2
leucine-rich repeat kinase 2
- PD
Parkinson's disease
- ROS
Ras of complex proteins
- COR
C-terminal of ROC
- Kin
kinase domain
- SEC-MALS
multiangle light scattering coupled to size-exclusion chromatography
- Gpp(NH)p
guanosine 5′-(β,γ-imido)triphosphate.