Journal of Biological Chemistry
Volume 292, Issue 13, 31 March 2017, Pages 5584-5592
EnzymologyStructural and Mechanistic Insights into Hemoglobin-catalyzed Hydrogen Sulfide Oxidation and the Fate of Polysulfide Products*Mechanism of Hemoglobin-catalyzed H2S Oxidation
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crystal structure
heme
hemoglobin
hydrogen sulfide
oxidation-reduction (redox)
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- *
This work was supported in part by National Institutes of Health Grants GM112455 (to R. B.) and DK111465 (to U.-S. C). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
The atomic coordinates and structure factors (code 5UCU) have been deposited in the Protein Data Bank (http://wwpdb.org/).
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The abbreviations used are:
- H2S
hydrogen sulfide
- Cys-SSH
cysteine persulfide
- CAM
carbamidomethyl
- FeIII-Hb
methemoglobin or ferric hemoglobin
- MSR
methionine synthase reductase
- TCEP
tris(2-carboxyethyl)phosphine.
© 2017 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.