Journal of Biological Chemistry
Volume 291, Issue 27, 1 July 2016, Pages 13999-14011
Molecular Bases of DiseaseDesign of a Genetically Stable High Fidelity Coxsackievirus B3 Polymerase That Attenuates Virus Growth in Vivo*
Under a Creative Commons license
open access
plus-stranded RNA virus
protein engineering
vaccine development
viral polymerase
virology
polymerase fidelity
Cited by (0)
The atomic coordinates and structure factors (codes 4ZPA, 4ZPB, 4ZP6, 4ZP7, 4ZP8, 4ZP9, 4ZPC, and 4ZPD) have been deposited in the Protein Data Bank (http://wwpdb.org/).
- *
This work was supported by National Institutes of Health Grant R01 AI059130 (to O. B. P.) and a LabEx Integrative Biology of Emerging Infectious Diseases program grant (to M. V.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
© 2016 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.