Journal of Biological Chemistry
Volume 276, Issue 51, 21 December 2001, Pages 48458-48465
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MOLECULAR BASIS OF CELL AND DEVELOPMENTAL BIOLOGY
Dynamin Isoform-specific Interaction with the Shank/ProSAP Scaffolding Proteins of the Postsynaptic Density and Actin Cytoskeleton*

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Dynamin is a GTPase involved in endocytosis and other aspects of membrane trafficking. A critical function in the presynaptic compartment attributed to the brain-specific dynamin isoform, dynamin-1, is in synaptic vesicle recycling. We report that dynamin-2 specifically interacts with members of the Shank/ProSAP family of postsynaptic density scaffolding proteins and present evidence that dynamin-2 is specifically associated with the postsynaptic density. These data are consistent with a role for this otherwise broadly distributed form of dynamin in glutamate receptor down-regulation and other aspects of postsynaptic membrane turnover.

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Published, JBC Papers in Press, October 2, 2001, DOI 10.1074/jbc.M104927200

*

This work was supported by National Institutes of Health Grant GM26701 (to R. B. V.).The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Present address: Dept. of Molecular, Cellular, and Developmental Biology, Yale University, 219 Prospect Ave., New Haven, CT 06520.