Control of Glucose-Metabolizing Enzymes in Preneoplastic Rat Liver

Abstract

Studies of the transient changes in the maximum catalytic capacities of glucose-metabolizing enzymes in preneoplastic rat liver revealed significant decreases in the activities of only two enzymes, glucokinase and hexosediphosphatase. The activities of hexokinase, glucose-6-phosphate dehydrogenase, and phospho-gluconate dehydrogenase increased threefold and there was a significant elevation of liver enzymes in the serum after 45 days of carcinogen treatment.