General Obstetrics and Gynecology ObstetricsPreeclampsia: Evidence for impaired shear stress–mediated nitric oxide release in uterine circulation☆
Section snippets
Subjects
This study was approved by the Ethical Committee of Huddinge University Hospital, and all women gave their informed consent to participate. Informed consent was obtained from 6 nulliparous women with preeclampsia, with a median age of 27 years (range, 22-36), and a median gestational age of 36 weeks (range, 31-39) who were undergoing cesarean delivery because of worsening of the preeclamptic state. Preeclampsia was defined as blood pressure ≥140/90 mm Hg and proteinuria exceeding >300 mg/24 h
Results
The arteries from women with preeclampsia (n = 6) and control subjects (n = 9) had similar diameters when equilibrated in physiologic sodium chloride solution alone at 50 mm Hg (212 ± 24 vs 215 ± 20 μm, respectively).
Comment
In this study and in a recent report,12 we have demonstrated that shear stress is a potent stimulus for nitric oxide–mediated vasodilatation to occur in isolated small myometrial arteries from healthy pregnant women. However, in arteries from women with preeclampsia, wall shear stress fails to induce vasodilatation; indeed, these arteries demonstrate vasoconstriction in response to flow-induced shear stress. Our findings are thus in agreement with the absence of flow-mediated vasodilatation
References (26)
- et al.
Abnormal endothelial cell function of resistance arteries from women with preeclampsia
Am J Obstet Gynecol
(1993) - et al.
Bradykinin-mediated relaxation of isolated maternal resistance arteries in normal pregnancy and preeclampsia
Am J Obstet Gynecol
(1996) - et al.
The role of nitric oxide in the pathogenesis of preeclampsia
Am J Obstet Gynecol
(1994) - et al.
Urine but not plasma nitric oxide metabolites are decreased in women with preeclampsia
Am J Obstet Gynecol
(1996) - et al.
Evaluation of nitric oxide as a mediator of severe preeclampsia
Am J Obstet Gynecol
(1996) - et al.
Role of nitric oxide in the regulation of vascular tone in pressurized and perfused resistance myometrial arteries from term pregnant women
Am J Obstet Gynecol
(1997) - et al.
Modulation of vascular tone by nitric oxide and endothelin 1 in myometrial resistance arteries from pregnant women at term
Am J Obstet Gynecol
(2000) - et al.
Effects of selected vasoconstrictor agonists on isolated omental artery from premenopausal nonpregnant women and from normal and preeclamptic pregnant women
Am J Obstet Gynecol
(1996) - et al.
Clinical and biochemical evidence of endothelial cell dysfunction in the pregnancy syndrome preeclampsia
Am J Hypertens
(1991) - et al.
Preeclampsia selectively impairs endothelium-dependent relaxation and leads to oscillatory activity in small omental arteries
J Clin Invest
(1998)
Loss of endothelium-dependent relaxation in myometrial resistance arteries in pre-eclampsia
Br J Obstet Gynaecol
Myogenic and endothelial properties in myometrial resistance arteries from women with preeclampsia
Hypertens Preg
Relationship between nitric oxide synthesis and increase in systolic blood pressure in women with hypertension in pregnancy
Hypertens Preg
Cited by (62)
Missing links in preeclampsia cell model systems of endothelial dysfunction
2023, Trends in Molecular MedicineMechanical forces on trophoblast motility and its potential role in spiral artery remodeling during pregnancy
2022, PlacentaCitation Excerpt :Some dissected small fetoplacental arteries from placenta and applied increments of intraluminal flow to determine the role of nitric oxide release in flow-induced dilation [30]. Some in situ studies compared isolated myometrial arteries from healthy gravid women with those from PE patients to look inside the shear stress-mediated release of nitric oxide in modulation of pressure- and norepinephrine-induced vascular tone [31]. Some studies have further applied modern techniques such as computational model to mimic blood flow in placenta and to determine the possible haemodynamic changes during the first trimester.
Endothelial maintenance in health and disease: Importance of sex differences
2017, Pharmacological ResearchAltered placental ion channel gene expression in preeclamptic high-altitude pregnancies
2023, Physiological GenomicsDietary supplements and vascular function in hypertensive disorders of pregnancy
2023, Pflugers Archiv European Journal of Physiology
- ☆
Reprint requests: Karolina-Rasa Kublickiene, MD, PhD, Department of Obstetrics and Gynaecology, Karolinska Institute, Huddinge University Hospital, 14186 Huddinge, Sweden. E-mail [email protected].