We integrated an ultra-broadband microwave circuit for direct sampling of single α-Hemolysin pores in a suspended bilipid membrane. Simultaneous direct current recordings reveal that we can monitor and correlate the radio-frequency transmission signal, with correspondence between open-close states of the direct current and the RF signals. This proves the ability of an RF-readout technique to perform real-time in-vitro recordings of pores. The technique thus holds great promise for research and drug screening applications, since the sampling rate of single channels can be drastically enhanced and the recording bandwidth allows for tracking the passage of single ions.
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