Labdane-Type Diterpenes Active against Acne from Pine Cones (Pinus densiflora)

 

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Abstract

Bioassay-guided extraction and fractionation of the aqueous methanolic extract of the cones of Pinus densiflora (Pinaceae) afforded one new labdane-type diterpene aldehyde, 15-nor-14-oxolabda-8(17),12E-diene-18-oic acid, along with eight known diterpenes. Their structures were elucidated using spectroscopic methods as well as by comparison with previously reported data. The isolates showed antibacterial (Propionibacterium acnes) and antifungal activities.

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Prof. Dr. Surk-Sik Moon

Department of Chemistry

Kongju National University

Kongju 314-701

Korea

Phone: +82-41-850-8495

Fax: +82-41-850-8479

Email: ssmoon@kongju.ac.kr

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