Gold(III)-Catalyzed Cyanosilylation of Ketones and Aldehydes

 

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Abstract

Gold(III) chloride was found to be a highly efficient catalyst for the cyanosilylation of various ketones and aldehydes. The reactions were complete within 30 minutes at room temperature in the presence of only one mol% gold(III) chloride, yielding the corresponding cyanohydrin trimethylsilyl ethers in very good yields. The isolated yields for the reactions of ketones were up to 98%, and the reactions of aldehydes gave 100% conversion, as monitored by ¹H NMR spectroscopy.

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These authors contributed equally to this work.