Synthesis of Bis- and Trisoxazole Derivatives via Suzuki-Miyaura Cross-Coupling Reaction and van Leusen Oxazole Synthesis

 

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Abstract

Both C ₂- and C ₃-symmetric oxazole derivatives are synthesized via the Suzuki-Miyaura cross-coupling and van Leusen oxazole synthesis. Here, bis- and triscarboxaldehydes were obtained via the Suzuki-Miyaura cross-coupling and further treated with p-toluenesulfonylmethyl isocyanide (TosMIC) in the presence of potassium carbonate as a base and methanol as a solvent to deliver the corresponding oxazole derivatives.

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