Subscribe to RSS
DOI: 10.1055/s-2007-990420
Lymph node gastrinoma in multiple endocrine neoplasia type 1– a diagnostic challenge
We report on the difficulty to differentiate between metastatic and primary lymph node gastrinoma in a 62-year-old female patient with multiple endocrine neoplasie type 1 (MEN1). At six and twelve months after resection of a retroduodenal lymph node gastrinoma, no signs of recurrence of gastrinoma were observed. Basal and peak gastrin levels during secretin test were normalized. An extensive exploration, including gastrointesinal endoscopy, endoscopic ultrasonography, and Ga-68-DOTATOC-PET/CT, did not reveal a primary duodenal or pancreatic tumour. Localization of gastrinomas in patients with MEN1 is challenging due to their small size, frequent duodenal location, and multiplicity. Therefore, primary lymph node gastrinoma remains an exclusion diagnosis and extensive follow-ups are required.