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Planta Med 1983; 48(8): 253-257
DOI: 10.1055/s-2007-969928
Research Articles

© Hippokrates Verlag Stuttgart

Accumulation of Quinolizidine Alkaloids in Plants and Cell Suspension Cultures: Genera Lupinus, Cytisus, Baptisia, Genista, Laburnum, and Sophora

M. Wink1 , L. Witte2 , T. Hartmann1 , C. Theuring1 , V. Volz1
  • 1Institut für Pharmazeutische Biologie der Technischen Universität Braunschweig, Bundesrepublik Deutschland
  • 2Gesellschaft für Biotechnologische Forschung mbH, Braunschweig, Bundesrepublik Deutschland
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Publication History

1983

Publication Date:
26 March 2007 (online)

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Abstract

The patterns of quinolizidine alkaloids in cell cultures of 10 species of Fabaceae were analyzed by high-resolution GLC and GLC-MS and compared with the alkaloids present in the leaves of the respective plants. Lupanine was produced in all 10 cell suspension cultures as the main alkaloid. It was accompanied by sparteine, tetrahydrorhombifoline, 17-oxosparteine, 13-hydroxylupanine, 4-hydroxylupanine, 17-oxolupanine, and 13-hydroxylupanine esters as minor alkaloids in some species. The alkaloid patterns of the plants differed markedly in that α-pyridone alkaloids were the major alkaloids in the genera Cytisus, Genista, Laburnum and Sophora but were not accumulated in the cell cultures. These data further support the assumption that the pathway leading to lupanine is the basic pathway of quinolizidine alkaloids biosynthesis and that the other alkaloids are derived from lupanine.

Key Word Index

Lupinus - Cytisus - Laburnum - Baptisia - Genista - Sophora - Fabaceae - Quinolizidine Alkaloids - Cell Suspension Cultures - Capillary GLC-MS

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