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Horm Metab Res 1985; 17(5): 256-258
DOI: 10.1055/s-2007-1013508
DOI: 10.1055/s-2007-1013508
Clinical
© Georg Thieme Verlag, Stuttgart · New York
Zinc Metabolism during Captopril Treatment
Further Information
Publication History
1983
1984
Publication Date:
14 March 2008 (online)
Summary
In 14 hypertensives the effect of captopril (angiotensin-converting enzyme inhibitor) treatment on red blood cell Na+, K+, Mg2+ and Zn2+ concentrations and on plasma Zn2+ concentrations were studied. Intraerythrocytic Zn2+ concentrations increased slightly, whereas plasma zinc concentrations decreased. The concurrence of hypozincemia with side effects resembling the symptoms of zinc deficiency such as loss of smell and taste suggests a role of alterations in zinc metabolism for the pharmacodynamics of captopril.
Key-Words:
Angiotensin Convening Enzyme Inhibitor - Zinc - Side Effects