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Horm Metab Res 1986; 18(11): 775-778
DOI: 10.1055/s-2007-1012433
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Effect of Verapamil on the Aldosterone-Stimulating Properties of Metoclopramide: In Vitro and In Vivo Studies

G. Opocher, A. Murgia, S. Rocco, D. D'Agostino, M. Boscaro, A. Menegus, F. Mantero
  • Istituto di Semeiotica Medica, University of Padova, Padova, Italy
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Publication History

1985

1985

Publication Date:
14 March 2008 (online)

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Summary

The role of calcium in the regulation of aldosterone secretion has been recently clarified. Angiotensin II and potassium stimulate aldosterone secretion through a calcium-entry dependent mechanism, while ACTH action is both calcium and cyclic AMP dependent. To establish whether also the socalled aldosterone dopaminergic regulatory system is calcium-dependent we have studied, in vitro and in vivo, the effect of verapamil, a calcium entry blocker agent, on the aldosterone-stimulating properties of the antidopaminergic drug, metoclopramide. In the rat adrenal cells perfusion system, verapamil blocked both angiotensin II and metoclopramide-stimulated aldosterone. This effect on metoclopramide action seems to be present also in vivo in normal subjects: in fact aldosterone response was slightly but significantly reduced after pretreatment with verapamil. In conclusion the results suggest that also the dopaminergic system could regulate aldosterone secretion through calcium-mediated mechanisms.

Key-Words

Verapamil - Aldosterone - Metoclopramide

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