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Thorac Cardiovasc Surg 1998; 46(2): 77-83
DOI: 10.1055/s-2007-1010194
Original Cardiovascular

© Georg Thieme Verlag Stuttgart · New York

Pericardial Substitution After Cardiopulmonary Bypass Surgery: A Trial of an Absorbable Patch

U. U. Nkere, S. A. Whawell, C. E. Sarraf, J. B. Schofield, P. A. O'Keefe
  • Royal Postgraduate Medical School, Hammersmith Hospital, London, England
Further Information

Publication History

1997

Publication Date:
19 March 2008 (online)

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Abstract

Primary closure of the pericardium affords some protection against adhesion formation and the consequent hazards of resternotomy. However, its completion may be impractical and hazardous, and therefore the pursuit of an ideal pericardial substitute has prompted much research. Twenty calves were divided into 3 groups for the study. All animals underwent right postero- lateral thoracotomy. The test group (group X), consisting of 6 animals, received a poly-ß-hydroxybutyrate patch (PHB) to dose the pericardium following cardiopulmonary bypass (CPB). In group Y (9 animals) the pericardium was left open following CPB. Croup Z (5 animals) also had their pericardium left open but did not undergo CPB (non-CPB). The Plasminogen activating activity (PAA) of homogenates of pericardial tissue samples were measured in 5 animals in group X, and in 5 in group Z. Samples were taken at three time points from the time of pericardiotomy, and at reoperation 4 weeks later. In group X (CPB) there was a significant reduction in the PAA during the Operation with some recovery at reoperation. The reduction in the pericardial PAA of group Z (non-CPB) animals did not reach significance. For both group X and group Z the progress of mesothelial damage, compared with that at zero time, showed a significant increase. In addition, their pericardial inflammatory features became more apparent in the later samples but more significantly in group Z. This study demonstrated no significant short-term differences in adhesion formation or postoperative coronary anatomy visibility between any of the groups. At reoperation the patch material contained pronounced macrophage activity but no regenerative mesothelium. There were no infective episodes in any of the animals studied. Furthermore, this study suggests that CPB in comparison to non-CPB has a significant affect on pericardial PAA.

Key words

Pericardial Substitution - Pericardial substitute - Pericardial adhesions

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