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Horm Metab Res 1992; 24(9): 443-445
DOI: 10.1055/s-2007-1003355
Clinical

© Georg Thieme Verlag, Stuttgart · New York

A Correlative Study on Serum Cholylglycine Levels in Hepatobiliary Disease

B. S. Qiu1 , C. H. Cho2 , C. W. Ogle2
  • 1Department of Internal Medicine, The First Affiliated Hospital of the Shantou University Medical College, Shantou, P. R. China
  • 2Department of Pharmacology, Faculty of Medicine, University of Hong Kong, Hong Kong
Further Information

Publication History

1991

1992

Publication Date:
14 March 2008 (online)

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Summary

The serum cholylglycine (CG), alanine aminotransferase (ALT) and total bilirubin levels were studied in 210 patients with hepatobiliary disease and in 70 healthy subjects. Serum CG concentrations in all the hepatobiliary diseases were found to be significantly higher than those of their controls. Patients with abnormal increases in ALT and bilirubin levels also showed raised CG concentrations; however, some patients with normal ALT and bilirubin levels, still had markedly elevated CG values. Patients with hepatic cirrhosis had high serum CG levels, followed, in descending order, by chronic active hepatitis and chronic persistent hepatitis. In the cholecystitis and cholelithiasis cases, their CG levels were significantly higher than those of the controls but lower than the values in hepatic disease patients; however, more cholecystitis cases had abnormally high serum bilirubin levels than CG. The results also show that serum CG concentrations vary in the different hepatobiliary diseases, and that serial CG measurements are more sensitive than measuring ALT and bilirubin levels in the diagnosis of hepatic diseases. Serum CG can be used as an index for evaluating the activity of chronic hepatitis; it can also be employed as a diagnostic tool in cholecystitis and cholelithiasis.

Key words

Cholylglycine - Hepatobiliary Disease - Alanine Aminotransferase - Bilirubin

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