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Planta Med 1987; 53(4): 329-332
DOI: 10.1055/s-2006-962729
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© Georg Thieme Verlag Stuttgart · New York

A Uterine Relaxant Compound from Zingiber cassumunar

D. Kanjanapothi1 , P. Soparat2 , A. Panthong1 , P. Tuntiwachwuttikul3 , V. Reutrakul4
  • 1Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50002, Thailand.
  • 2Faculty of Nursing, Chiang Mai University, Chiang Mai 50002, Thailand.
  • 3Department of Medical Science, Ministry of Public Health, Bangkok 10100, Thailand.
  • 4Department of Chemistry, Mahidol University, Bangkok 10400, Thailand.
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Publication History

1986

Publication Date:
24 January 2007 (online)

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Abstract

(E)-4-(3′,4′-Dimethoxyphenyl)-but-3-en-1-ol, compound D, was present in significant amounts in the hexane extract of Zingiber cassumunar Roxb. (Zingibereceae). It exhibited a dose related uterine relaxant effect when tested in the rat uterus (non-pregnant), in situ experiment. The uterine response of pregnant rats varied with the stage of pregnancy, and the uterus of the post-implantation period was found to be the most sensitive. From a comparison of the dose-response regression lines of compound D and reference drugs obtained from isolated rat uterus experiment, the potency of compound D was lower than that of isoproterenol and papaverine, but higher than that of aminophylline. The uterine relaxant effect of compound D was not blocked by the preadministration of propranolol and the dose-response regression line of compound D paralleled only that of papaverine. The findings suggest that compound D does not act via β-adrenergic receptor stimulation, and that compound D might share with papaverine a similar mechanism of action.

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