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Planta Med 1999; 65(5): 457-459
DOI: 10.1055/s-2006-960812
Letter

© Georg Thieme Verlag Stuttgart · New York

Inhibitory Effect of Luteolin 4′-O-Glucoside from Kummerowia striata and Other Flavonoids on Interleukin-5 Bioactivity

Keun Yeong Park1 , Seung-Ho Lee2 , Bo-Kyung Min1 , Kyong Soon Lee1 , Jae-Sue Choi3 , See Ryun Chung2 , Kyung Rak Min1 , Youngsoo Kim1
  • 1College of Pharmacy, Chungbuk National University, Cheongju, Korea
  • 2College of Pharmacy, Yeungnam University, Kyongsan, Korea
  • 3Department of Food and Life Science, Pukyong National University, Pusan, Korea
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Publication History

1998

1999

Publication Date:
04 January 2007 (online)

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Abstract

Interleukin (IL)-5 is a chemotactic factor of eosinophils, and promotes the growth and survival of eosinophils, which plays an important role in the eosinophilia-associated allergic inflammation. In this study, luteolin 4′-O-glucopyranoside was identified as the IL-5 inhibitor from Kummerowia striata Thunb. (Leguminosae) by activity-guided fractionation followed by structural analysis compared with reported spectral data. The flavone compound exhibited dose-dependent inhibitory effect on IL-5 bioactivity with 95% inhibition at 30 µM, 79% at 15 µM, 60% at 7.5 µM, 54% at 3.8 µM and 29% at 1.9 µM, where 50% of inhibition (IC50) value was shown at the concentration of 3.7 µM. Furthermore, the inhibitory effect on IL-5 bioactivity by other flavonoid compounds available was estimated. In view of the IC50 values, the inhibitory potency on IL-5 bioactivity was in order of luteolin 4′-O-glucopyranoside > cosmosiin (14.2 µM) ≅ apigenin (16.4 µM) ≅ luteolin (18.7 ≅M) > quercimeritrin (27.3 µM)≅kaempferol (30.0 µM).

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