Antimicrobial Activity and Stability of Tingenone Derivatives

Uthai Sotanaphun; Vimolmas Lipipun; Rutt Suttisri; Rapepol Bavovada

doi:10.1055/s-2006-960809

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Planta Med 1999; 65(5): 450-452
DOI: 10.1055/s-2006-960809

Letter

Antimicrobial Activity and Stability of Tingenone Derivatives

Uthai Sotanaphun¹ , Vimolmas Lipipun² , Rutt Suttisri² , Rapepol Bavovada²

¹Faculty of Pharmacy, Silpakorn University, Nakorn-Pathom, Thailand
²Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand

Further Information

Publication History

1998

1999

Publication Date:
04 January 2007 (online)

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Abstract

Quinone-methide triterpenes of the tingenone series were evaluated for their antimicrobial activity. These compounds were effective against Bacillus cereus, B. subtilis, Sarcinalutea, Staphylococcus aureus, Microsporum gypseum and a Gramnegative bacterium, Klebsiella pneumoniae. Under acidic conditions, the quinone-methide part of these compounds rear ranged into the divinyl-phenolic system, and the antimicrobial activity was thus lost.

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