Inhibition of Chitin Synthase II by Catechins from Stem Bark of Taxus cuspidata

Sung-Uk Kim; Eui-Il Hwang; Ji-Youn Nam; Kwang-Hee Son; Song-Hae Bok; Hong-Eun Kim; Byoung-Mog Kwon

doi:10.1055/s-2006-960453

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Planta Med 1999; 65(1): 97-98
DOI: 10.1055/s-2006-960453

Letter

Inhibition of Chitin Synthase II by Catechins from Stem Bark of Taxus cuspidata

Sung-Uk Kim¹ , Eui-Il Hwang¹ , Ji-Youn Nam² , Kwang-Hee Son¹ , Song-Hae Bok² , Hong-Eun Kim³ , Byoung-Mog Kwon²

¹Plant Protectants R.U., Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea
²Protein Regulator R.U., Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea
³Department of Forestry, College of Agriculture, Chungbuk National University, Cheongju, Korea

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Publication History

1998

1998

Publication Date:
04 January 2007 (online)

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Abstract

Two flavonoids, (±)-catechin and (-)-epicatechin, were isolated from the stem bark of Taxus cuspidata by monitoring chitin synthase II inhibitory activity. The compounds inhibit chitin synthase II with an IC₅₀ of 15 and 29 µg/ml, respectively and appear to be selective for chitin synthase II. They did not inhibit chitin synthase III.

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