Inhibition of Lipid Peroxidation and Superoxide Generation by Diterpenoids from Rosmarinus officinalis

Hiroyuki Haraguchi; Takashi Saito; Nobuyuki Okamura; Akira Yagi

doi:10.1055/s-2006-958094

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Planta Med 1995; 61(4): 333-336
DOI: 10.1055/s-2006-958094

Papers

Inhibition of Lipid Peroxidation and Superoxide Generation by Diterpenoids from Rosmarinus officinalis

Hiroyuki Haraguchi¹ , Takashi Saito¹ , Nobuyuki Okamura² , Akira Yagi²

¹Faculty of Engineering, Fukuyama University, Gakuen-cho, Fukuyama 729-02, Japan
²Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Gakuen-cho, Fukuyama 729-02, Japan

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Publication History

1994

1994

Publication Date:
04 January 2007 (online)

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Abstract

Four diterpenoids, carnosic acid (1), carnosol (2), rosmanol (3), and epirosmanol (4), were isolated as antioxidative agents from the leaves of Rosmarinus officinalis by bioassay-directed fractionation. These diterpenoids inhibited superoxide anion production in the xanthine/xanthine oxidase system. Mitochondrial and microsomal lipid peroxidation induced by NADH or NADPH oxidation were also completely inhibited by these diterpenes at the concentration of 3-30 µM. Furthermore, carnosic acid protected red cells against oxidative hemolysis. These phenolic diterpenes were shown to be effective to protect biological systems against oxidative stresses.

Key words

Rosmarinus officinalis - Labiatae - carnosic acid - carnosol - rosmanol - epirosmanol - lipid peroxidation - superoxide anion

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