The Antipsoriatic Mahonia aquifolium and its Active Constituents; II. Antiproliferative Activity against Cell Growth of Human Keratinocytes

Klaus Müller; Klaus Ziereis; Ingo Gawlik

doi:10.1055/s-2006-958005

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Planta Med 1995; 61(1): 74-75
DOI: 10.1055/s-2006-958005

Letter

The Antipsoriatic Mahonia aquifolium and its Active Constituents; II. Antiproliferative Activity against Cell Growth of Human Keratinocytes

Klaus Müller, Klaus Ziereis, Ingo Gawlik

Institut für Pharmazie, Universität Regensburg, Universitätsstr. 31, D-93040 Regensburg, Germany

Further Information

Publication History

1994

1994

Publication Date:
04 January 2007 (online)

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Abstract

The extract of the bark of Mahonia aquifolium is an inhibitor of keratinocyte growth with an IC₅₀ of 35 µM. Of its main alkaloids tested, berberine inhibited cell growth to the same extent as did the Mahonia extract, while the benzylisoquinoline alkaloids berbamine and oxyacanthine were more potent inhibitors by a factor of three.

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