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Planta Med 1997; 63(5): 461-463
DOI: 10.1055/s-2006-957734
Papers
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

New Sesquiterpenes from the Roots of Ligularia dentata

Kun Gao1 , Li Yang2 , Zhongjian Jia1
  • 1Department of Chemistry at Lanzhou University, Lanzhou 730 000, People's Republic of China
  • 2Stata Key Laboratory of Applied Organic Chemistry at Lanzhou University, Lanzhou 730 000, People's Republic of China
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Publication History

1996

1997

Publication Date:
04 January 2007 (online)

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Abstract

Phytochemical investigation of the roots of Ligularia dentata has resulted in the isolation of three new bisabolane sesquiterpenes: 1α,3β,10,11 -tetrahydroxy-2α,5α,8-triangeloyl-oxybisabola-(7)14-en-4-one (1), 1α,3β,10-trihydroxy-11 -methoxy-2α,5α,8-triangeloyloxybisabola-7(14)-en-4-one(2), and lα, 3β,10-trihydroxy-2α,5α,8-triangeloyloxybisabola-7(14),11(12)-dien-4-one (3). Their structures were elucidated with spectro-scopic methods and 2D-NMR techniques as well as chemical transformations. In addition, three known phenolic norsesquiterpenes, liguhodgsonal (4), ligujapone (5), and 2-hydroxy-platyphyllide (6) have also been obtained.

key words

Ligularia dentata - Compositae - roots - sesquiterpenes - bisabolane

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