Planta Med 2004; 70(11): 1085-1087
DOI: 10.1055/s-2004-832652
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Antiviral and Antiplasmodial Spirodihydrobenzofuran Terpenes from the Fungus Stachybotrys nephrospora

Supaporn Sawadjoon1 , Prasat Kittakoop2 , Masahiko Isaka2 , Kanyawim Kirtikara2 , Siribhorn Madla2 , Yodhathai Thebtaranonth1 , 2
  • 1Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
  • 2National Center for Genetic Engineering and Biotechnology (BIOTEC), NSTDA, Pathumthani, Thailand
Further Information

Publication History

Received: March 26, 2004

Accepted: July 12, 2004

Publication Date:
18 November 2004 (online)

Abstract

Two known spirodihydrobenzofuran terpenes (1 and 2) were isolated from a mycelium extract of the fungus Stachybotrys nephrospora BCC 3900. Compound 1 (Mer-NF5003F or stachybotrydial) exhibited potent antiviral activity (the IC50 value of 4.32 μg/mL) comparable to the standard drug, acyclovir, while compound 2 was inactive against the HSV-1 virus. Both 1 and 2 possessed antiplasmodial activity (IC50 values of 0.85 and 0.15 μg/mL for 1 and 2, respectively), and were not toxic towards the Vero cell line. A regiospecific conversion of the dialdehyde 1 to the lactone 2 proceeded simply under acidic conditions.

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Dr. Prasat Kittakoop

National Center for Genetic Engineering and Biotechnology

NSTDA

Thailand Science Park

113 Paholyothin Road

Klong 1

Klong Luang

Pathumthani 12120

Thailand

Phone: +66-2-564-6700 ext. 3560

Fax: +66-2-564-6707

Email: prasat@biotec.or.th

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