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Cent Eur Neurosurg 2005; 66(2): 92-94
DOI: 10.1055/s-2004-832473
Case Report

© Georg Thieme Verlag Stuttgart · New York

Ceftriaxone-Induced Symptomatic Pseudolithiasis Mimicking ICP Elevation

Scheinbare Hirndruckerhöhung durch Ceftriaxon induzierte symptomatische PseudolithiasisC. Evliyaoglu1 , T. Kizartici2 , G. Bademci1 , B. Unal3 , S. Keskil1
  • 1Department of Neurosurgery, Kirikkale University School of Medicine, Kirikkale, Turkey
  • 2Consultant, County Hospital, Odemis, Turkey
  • 3Department of Radiology, Kirikkale University School of Medicine, Kirikkale, Turkey
Further Information

Publication History

Publication Date:
22 April 2005 (online)

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Abstract

In neurosurgery, ceftriaxone is a widely used, third generation cephalosporin for the treatment of CNS infections and perioperational prophylaxis. Recent studies have demonstrated that ceftriaxone induces reversible precipitates in the gallbladder. This complication is referred to as “biliary pseudolithiasis”, and it has symptoms similar to the raised intracranial pressure (ICP) symptoms of the perioperative period. Symptomatic biliary pseudolithiasis should be kept in mind in all pediatric neurosurgery cases under ceftriaxone therapy in order to prevent unnecessary postoperative investigations and surgery.

Zusammenfassung

In der Neurochirurgie ist Ceftriaxon ein häufig verwendetes Cefalosporin der dritten Generation zur Behandlung von Infektionen des zentralen Nervensystems und zur perioperativen Prophylaxe. Neueste Studien haben gezeigt, dass Ceftriaxon reversible Ablagerungen in der Gallenblase hervorruft. Diese Komplikation wird als Pseudolithiasis der Galle bezeichnet und zeigt ähnliche Symptome wie ein erhöhter intrakranieller Druck während der perioperativen Periode. In der Kinderneurochirurgie sollte deshalb unter Ceftriaxon-Therapie eine symptomatische Pseudolithiasis der Galle nicht außer Acht gelassen werden, um unnötige postoperative Maßnahmen und Eingriffe zu vermeiden.

Key words

Cephalosporin - antibiotic prophylaxis - children - surgery

Schlüsselwörter

Cefalosporin - Antibiotikaprophylaxe - Kinder - Chirurgie

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Cetin EvliyaogluM.D. 

Yilmaz Çolpan Sok. 7/3

Oran Sitesi

06450 Oran, Ankara

Turkey

Phone: +90/3 18/2 24 00 87

Fax: +90/3 18/2 25 28 19

Email: cevliyaoglu@hotmail.com

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