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Minim Invasive Neurosurg 2004; 47(5): 266-272
DOI: 10.1055/s-2004-830076
Original Article
© Georg Thieme Verlag Stuttgart · New York

Image-Guided Robotic Radiosurgery in a Rat Glioma Model

T.  G.  Psarros1 , B.  Mickey1 , K.  Gall2 , J.  Gilio2 , J.  Delp2 , C.  White3 , J.  Drees1 , M.  Willis3 , D.  Pistemmna2 , C.  A.  Giller1
  • 1Departments of Neurosurgery, University of Texas Southwestern School of Medicine, Dallas, TX, USA
  • 2Department of Radiation Oncology, University of Texas Southwestern School of Medicine, Dallas, TX, USA
  • 3Department of Pathology, University of Texas Southwestern School of Medicine, Dallas, TX, USA
Further Information

Publication History

Publication Date:
02 December 2004 (online)

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Abstract

Despite the proven efficacy of radiosurgery for the treatment of brain tumors, limited histological information is available after treatment that might allow a better understanding of the relationship between radiation dose, the volume treated, and the response of the surrounding brain to the delivered radiation. The use of an animal model could provide the opportunity to clarify these relationships and answer several other key questions arising in clinical practice. We show here that treatment of small animals with radiosurgery is feasible using a robotically controlled linear accelerator, which offers the advantages of radiosurgery and preserves the potential for fractionated regimens without rigid immobilization. Specifically, we demonstrate the use of a robotically driven linear accelerator to provide radiosurgical treatment to a rat brain tumor model.

Key words

Radiosurgery - 9L glioma - Cyberknife

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Thomas G. PsarrosM. D. 

University of Texas Southwestern Medical Center

5323 Harry Hines Blvd.

Dallas, Texas 75390-8855

USA

Phone: +1-214-648-3234

Email: tompsarros@aol.com

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