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Planta Med 2001; 67(9): 876-877
DOI: 10.1055/s-2001-18860
Letter

© Georg Thieme Verlag Stuttgart · New York

Diarylheptanoids with Free Radical Scavenging and Hepatoprotective Activity in vitro from Curcuma longa

Eun-Kyoung Song1 , Hyun Cho1 , Jeong-Sik Kim1 , Na-Young Kim1 , Nyeon-Hyeong An1 , Jeong-Ah Kim2 , Seung-Ho Lee2 , Youn-Chul Kim1
  • 1 MRRC and College of Pharmacy, Wonkwang University, Iksan, Korea
  • 2 College of Pharmacy, Yeungnam University, Kyongsan, Korea
Further Information

Publication History

December 12, 2000

April 22, 2001

Publication Date:
06 December 2001 (online)

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Abstract

Assay-guided fractionation of the EtOAc soluble fraction of the rhizomes of Curcuma longa furnished three DPPH free radical scavenging diarylheptanoids, curcumin (1), demethoxycurcumin (2), and bisdemethoxycurcumin (3). Compounds 1 - 3 showed the DPPH radical scavenging effects with IC50 values of 2.8, 39.2, 308.7 μM, respectively. L-Ascorbic acid and resveratrol as positive controls exhibited IC50 values of 22.5 and 25.0 μM, respectively. Compounds 1 - 3 showed significant hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC50 values of 1 - 3 are 86.9, 70.7, and 50.2 μM, respectively. Silybin (EC50 = 69.0 μM) and silychristin (EC50 = 82.7 μM) were used as positive controls.

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Prof. Dr. Youn-Chul Kim

MRRC and College of Pharmacy

Wonkwang University

Iksan 570-749

South Korea

Email: yckim@wonkwang.ac.kr

Fax: +82-63-852-8837

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