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Planta Med 2001; 67(2): 166-168
DOI: 10.1055/s-2001-11501
Letter

© Georg Thieme Verlag Stuttgart · New York

Lignans as Anti-Tumor-Promoter from the Seeds of Hernandia ovigera

Chihiro Ito1 , Masataka Itoigawa2,*, Masakazu Ogata3 , Xiao Yang Mou3 , Harukuni Tokuda3 , Hoyoku Nishino3 , Hiroshi Furukawa1
  • 1 Faculty of Pharmacy, Meijo University, Tempaku, Nagoya, Japan
  • 2 Tokai Gakuen University, Miyoshi, Aichi, Japan
  • 3 Department of Biochemistry, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan
Further Information

Publication History

March 23, 2000

June 18, 2000

Publication Date:
31 December 2001 (online)

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Abstract

Seven lignans (2 - 8) isolated from the seeds of Hernandia ovigera L. (Hernandiaceae) were tested for their inhibitory effects on Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol 13-acetate in Raji cells. Using a primary screening test, all the lignans showed inhibitory activity with IC50 470 - 590 mol ratio/32 pmol TPA. The data demonstrated that these lignans might be valuable anti-tumor-promoters.

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Masataka Itoigawa,Ph.D. 

Tokai Gakuen University

Ukigai

Miyoshi-cho

Nishikamo-gun

Aichi 470-0207

Japan

Email: itoigawa@tokaigakuen-c.ac.jp

Fax: +81-5613-6-6757

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