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CC BY-NC-ND 4.0 · South Asian J Cancer 2023; 12(02): 217-220
DOI: 10.1055/s-0042-1757425
Case Report

Rare Case of Extracranial Metastases in a Patient with IDH-Mutant Glioblastoma

Rishan Thimma Sudarsan
1   Department of Radiation Oncology, Neuro-Oncology Cancer Management Team, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India
,
Vishnu Ramanujan
2   Department of Orthopedic Oncology, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India
,
Adhithyan Rajendran
3   Department of NeuroRadiology, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India
,
Sadiya Shafi 
4   Department of NeuroPathology, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India
,
Sushma Patil
4   Department of NeuroPathology, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India
,
Siddhartha Ghosh
5   Department of Neurosurgery, Apollo Hospitals, Chennai, Tamil Nadu, India
,
Rakesh Jalali
1   Department of Radiation Oncology, Neuro-Oncology Cancer Management Team, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India
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Abstract

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Rishan Thimma Sudarsan

Glioblastoma are known for its aggressive intracranial course of disease, where the overall survival is less than 18 months. Of late, the World Health Organization has reclassified and renamed secondary glioblastomas as isocitrate dehydrogenase (IDH)-mutant grade 4 astrocytomas, which is relatively better than its IDH wild-type counterpart; however, overall survival remains poor. In such tumors, metastases outside the craniospinal neuraxis is very rare, and does sometimes present with symptoms which create a diagnostic dilemma and arriving at such diagnosis is still challenging even for the best of the clinicians worldwide. Here we present such a rare case scenario, where a grade 4 astrocytoma that has transformed from a low-grade glioma, presenting with bone metastases, its workup, treatment, and various possible mechanisms underlying such a rare event, and the need of such clinical scenario especially long-term survivors to be wary of distant metastases.

Keywords

astrocytoma - extracranial - glioblastoma - IDH - metastases


Publication History

Article published online:
31 December 2022

© 2022. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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