Thorac Cardiovasc Surg 2022; 70(S 02): S67-S103
DOI: 10.1055/s-0042-1743027
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Monday, February 21
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Paediatric Cardiovascular Magnetic Resonance Reference Values for Biventricular Volumes Derived from Different Contouring Techniques and Biatrial Volumes

S. Hinz
1   Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Deutschland
,
S. Krupickova
2   Royal Brompton Hospital, London, United Kingdom
,
A. Caliebe
1   Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Deutschland
,
R. Wage
1   Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Deutschland
,
A. Uebing
1   Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Deutschland
,
I. Voges
1   Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Deutschland
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Background: We sought to create two sets of biventricular reference values for different CMR postprocessing techniques and to establish CMR reference values for atrial volumes.

Method: CMR datasets of 157 healthy children with a median age of 13.8 ± 2.8 years were analyzed. Biventricular end-diastolic and end-systolic volumes (LVEDV, LVESV, RVEDV, and RVESV), ejection fraction (RVEF and LVEF), and myocardial mass (LVMM and RVMM) were measured from short-axis images by applying two different techniques: (1) papillary muscles, trabeculations, and the moderator band were included in the ventricular volume and excluded from the ventricular mass; and (2) papillary muscles, trabeculations, and the moderator band were excluded from the ventricular volume and included in the ventricular mass. Biatrial volumes (LAmin, LAmax, RAmin, and RAmax) were measured using the biplane or monoplane area–length method. Reference curves were created with the lambda mu sigma method.

Results:

Average measurements for children from 4–10 years are as follows:

Contouring method 1: LVEDVi, 77.4 ± 12.0 mL/m2; LVESVi, 30.7 ± 6.3 mL/m2; RVEDVi, 78.2 ± 12.7 mL/m2; RVESVi, 31.9 ± 7.0 mL/m2; LVMMi, 43.1 ± 6.2 g/m2; and RVMMi, 17.1 ± 3.2 g/m2.

Contouring method 2: LVEDVi, 72.9 ± 11.4 mL/m2; LVESVi, 26.2 ± 6.1 mL/m2; RVEDVi, 66.4 ± 11.5 mL/m2; RVESVi, 24.4 ± 5.2 mL/m2; LVMMi, 48.1 ± 7.4 g/m2; and RVMMi, 25.2 ± 4.9 g/m2.

Atrial volumes biplane method: LAmin 10.2 ± 3.3 mL/m2; and LAmax, 27.4 ± 5.7 mL/m2.

Atrial volumes monoplane method (four-chamber view): LAmin, 10.2 ± 3.5 mL/m2; LAmax, 28.8 ± 7.4 mL/m2; RAmin, 14.1 ± 6.3 mL/m2; and RAmax, 27.0 ± 11.4 mL/m2.

Average measurements for children from 11 to 18 years are as follows:

Contouring method 1: LVEDVi, 88.7 ± 14.9 mL/m2; LVESVi, 38.3 ± 8.6 mL/m2; RVEDVi, 91.9 ± 16.8 mL/m2; RVESVi, 42.0 ± 9.6 mL/m2; LVMMi, 52.1 ± 10.5 g/m2; and RVMMi, 18.7 ± 3.8 g/m2.

Contouring method 2: LVEDVi, 82.6 ± 14.2 mL/m2; LVESVi, 32.4 ± 7.8 mL/m2; RVEDVi, 78.0 ± 14.7 mL/m2; RVESVi, 31.9 ± 7.8 mL/m2; LVMMi, 58.0 ± 12.0 g/m2; and RVMMi, 28.1 ± 6.7 g/m2.

Atrial volumes biplane method: LAmin, 12.9 ± 4.4 mL/m2; and LAmax, 31.8 ± 8.8 mL/m2.

Atrial volumes monoplane method (four-chamber view): LAmin, 13.6 ± 4.9 mL/m2; LAmax, 34.1 ± 9.1 mL/m2; RAmin, 19.2 ± 6.8 mL/m2; and RAmax 34.2 ± 9.6 mL/m2.

Conclusion: The provided CMR reference values can be of use for the routine analysis of CMR studies in children with congenital and acquired heart disease, as well as for research purposes.



Publication History

Article published online:
12 February 2022

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