Download PDF
CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2021; 31(04): 990-997
DOI: 10.1055/s-0041-1741046
Case Series

Case Series of Applications of Resting State Functional MRI in Brain Tumor Surgery: A Novel Technique

Arpita Sahu
1   Department of Radiodiagnosis, Tata Memorial Hospital, Homi Bhabha National Institute Mumbai, Maharashtra, India
,
Vineeth Kurki
1   Department of Radiodiagnosis, Tata Memorial Hospital, Homi Bhabha National Institute Mumbai, Maharashtra, India
,
Antariksh Vijan
1   Department of Radiodiagnosis, Tata Memorial Hospital, Homi Bhabha National Institute Mumbai, Maharashtra, India
,
Amit Janu
1   Department of Radiodiagnosis, Tata Memorial Hospital, Homi Bhabha National Institute Mumbai, Maharashtra, India
,
Prakash Shetty
2   Department of Neurosurgery, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India
,
Aliasgar Moiyadi
2   Department of Neurosurgery, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India
› Author Affiliations
› Further Information
   Permissions and Reprints

Abstract

Background The extent of resection for brain tumors is a critical factor in determining the oncologic outcome for a patient. However, a balance between preservation of neurological function and maximal resection is essential for true benefit.

Functional magnetic resonance imaging (fMRI) is one of the approaches that augments the neurosurgeon's ability to attain maximal safe resection by providing preoperative mapping. It may not be possible to perform awake craniotomy with intraoperative localization by direct cortical stimulation in all patients, such as children and those with neurocognitive impairment. Task-based fMRI may have limited value in these cases due to low patient cooperability.

Methods In this article we present in a case-based format, the various clinical scenarios where resting state fMRI (rs-fMRI) can be helpful in guiding neurosurgical resection. rs-fMRI of the patients has been acquired on Philips 1.5 T system. Seed voxel method has been used for processing and analysis.

Conclusion rs-fMRI does not require active patient cooperation to generate useful information and thus can be a promising tool in patients unable to cooperate for task-based studies.

Keywords

craniotomy - magnetic resonance imaging - resting state functional MRI

Declaration of Patient Consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.


Financial Support and Sponsorship

Nil.




Publication History

Article published online:
10 January 2022

© 2022. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Fisicaro RA, Jost E, Shaw K, Brennan NP, Peck KK, Holodny AI. Cortical plasticity in the setting of brain tumors. Top Magn Reson Imaging 2016; 25 (01) 25-30
    CrossrefPubMedGoogle Scholar
  • 2 Bogomolny DL, Petrovich NM, Hou BL, Peck KK, Kim MJ, Holodny AI. Functional MRI in the brain tumor patient. Top Magn Reson Imaging 2004; 15 (05) 325-335
    CrossrefPubMedGoogle Scholar
  • 3 Jost E, Christiansen MH, Brennan N, Holodny A. Behavioral advantage in confrontation naming performance in brain tumor patients with left-frontal tumors. In: Conference Proceedings of the Society for the Neurobiology of Language 2014;6:86
    Google Scholar
  • 4 Wood JM, Kundu B, Utter A. et al. Impact of brain tumor location on morbidity and mortality: a retrospective functional MR imaging study. AJNR Am J Neuroradiol 2011; 32 (08) 1420-1425
    CrossrefPubMedGoogle Scholar
  • 5 Biswal B, Yetkin FZ, Haughton VM, Hyde JS. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med 1995; 34 (04) 537-541
    CrossrefPubMedGoogle Scholar
  • 6 Voets NL, Plaha P, Parker Jones O, Pretorius P, Bartsch A. Presurgical localization of the primary sensorimotor cortex in gliomas: when is resting state fMRI beneficial and sufficient?. Clin Neuroradiol 2021; 31 (01) 245-256
    CrossrefPubMedGoogle Scholar
  • 7 Posse S, Ackley E, Mutihac R. et al. High-speed real-time resting-state FMRI using multi-slab echo-volumar imaging. Front Hum Neurosci 2013; 7: 479
    CrossrefPubMedGoogle Scholar
  • 8 Mitz AR, Wise SP. The somatotopic organization of the supplementary motor area: intracortical microstimulation mapping. J Neurosci 1987; 7 (04) 1010-1021
    CrossrefPubMedGoogle Scholar
  • 9 Chung GH, Han YM, Jeong SH, Jack Jr CR. Functional heterogeneity of the supplementary motor area. AJNR Am J Neuroradiol 2005; 26 (07) 1819-1823
    PubMedGoogle Scholar
  • 10 Serrien DJ, Strens LH, Oliviero A, Brown P. Repetitive transcranial magnetic stimulation of the supplementary motor area (SMA) degrades bimanual movement control in humans. Neurosci Lett 2002; 328 (02) 89-92
    CrossrefPubMedGoogle Scholar
  • 11 Krainik A, Lehéricy S, Duffau H. et al. Role of the supplementary motor area in motor deficit following medial frontal lobe surgery. Neurology 2001; 57 (05) 871-878
    CrossrefPubMedGoogle Scholar
  • 12 Krainik A, Duffau H, Capelle L. et al. Role of the healthy hemisphere in recovery after resection of the supplementary motor area. Neurology 2004; 62 (08) 1323-1332
    CrossrefPubMedGoogle Scholar
  • 13 Nelson L, Lapsiwala S, Haughton VM. et al. Preoperative mapping of the supplementary motor area in patients harboring tumors in the medial frontal lobe. J Neurosurg 2002; 97 (05) 1108-1114
    CrossrefPubMedGoogle Scholar
  • 14 Corballis MC. From mouth to hand: gesture, speech, and the evolution of right-handedness. Behav Brain Sci 2003; 26 (02) 199-208 , discussion 208–260
    CrossrefPubMedGoogle Scholar
  • 15 Brennan NP, Peck KK, Holodny A. Language mapping using fMRI and direct cortical stimulation for brain tumor surgery: the good, the bad, and the questionable. Top Magn Reson Imaging 2016; 25 (01) 1-10
    CrossrefPubMedGoogle Scholar
  • 16 Palanca BJA, Mitra A, Larson-Prior L, Snyder AZ, Avidan MS, Raichle ME. Resting-state functional magnetic resonance imaging correlates of sevoflurane-induced unconsciousness. Anesthesiology 2015; 123 (02) 346-356
    CrossrefPubMedGoogle Scholar
  • 17 Roland JL, Griffin N, Hacker CD. et al. Resting-state functional magnetic resonance imaging for surgical planning in pediatric patients: a preliminary experience. J Neurosurg Pediatr 2017; 20 (06) 583-590
    CrossrefPubMedGoogle Scholar
  • 18 Ulmer JL, Krouwer HG, Mueller WM, Ugurel MS, Kocak M, Mark LP. Pseudo-reorganization of language cortical function at fMR imaging: a consequence of tumor-induced neurovascular uncoupling. AJNR Am J Neuroradiol 2003; 24 (02) 213-217
    PubMedGoogle Scholar
  • 19 Jain RK, di Tomaso E, Duda DG, Loeffler JS, Sorensen AG, Batchelor TT. Angiogenesis in brain tumours. Nat Rev Neurosci 2007; 8 (08) 610-622
    CrossrefPubMedGoogle Scholar